Desyrel and Actemra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Desyrel (trazodone hydrochloride) and Actemra (tocilizumab). Common drug interactions include fatigue among females and infusion related reaction among males.

The phase IV clinical study analyzes what interactions people have when they take Desyrel and Actemra. It is created by eHealthMe based on reports of 82 people who take the same drugs from the FDA, and is updated regularly.

What is Desyrel?

Desyrel has active ingredients of trazodone hydrochloride. It is often used in insomnia. eHealthMe is studying from 6,595 Desyrel users. Check the latest studies of Desyrel.

What is Actemra?

Actemra has active ingredients of tocilizumab. It is often used in rheumatoid arthritis. eHealthMe is studying from 102,759 Actemra users. Check the latest studies of Actemra.

On Jul, 11, 2026

82 people who take Desyrel and Actemra together, and have interactions are studied.

What are the common drug interactions of Desyrel and Actemra, by gender? *:

female:

Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Abdominal pain upper
Alveolar osteitis (complication of wound healing following extraction of a tooth)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Arthropathy
Blood pressure diastolic increased
Blood pressure increased
Blood pressure systolic increased

male:

Infusion related reaction
Mass
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Fungaemia (fungi circulate in the blood)

What are the common drug interactions of Desyrel and Actemra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Asthenia (weakness)
Constipation
Dizziness
Fatigue (feeling of tiredness)
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Neutropenia (an abnormally low number of neutrophils)
Pneumonia
Pyrexia (fever)
Vertigo

20-29:

n/a

30-39:

Abdominal pain upper
Alveolar osteitis (complication of wound healing following extraction of a tooth)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Arthropathy
Blood pressure diastolic increased
Blood pressure increased
Blood pressure systolic increased
Diarrhoea
Dizziness

40-49:

Respiratory alkalosis (elevated blood ph due to excess breathing)
Vasculitis (inflammation of a blood vessel or blood vessels)
Influenza
Dyspnoea (difficult or laboured respiration)
Pneumonia

50-59:

n/a

60+:

Hepatic enzyme increased
Malignant melanoma (skin cancer rises from melancytes)
Drug ineffective
Synovitis (inflammation of the synovial membrane)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Fungaemia (fungi circulate in the blood)

* Approximation only. Some reports may have incomplete information.

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