Desyrel and Robitussin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Desyrel (trazodone hydrochloride) and Robitussin (guaifenesin). Common drug interactions include pain among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Desyrel and Robitussin. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Desyrel?

Desyrel has active ingredients of trazodone hydrochloride. It is often used in insomnia. eHealthMe is studying from 6,595 Desyrel users. Check the latest studies of Desyrel.

What is Robitussin?

Robitussin has active ingredients of guaifenesin. eHealthMe is studying from 3,532 Robitussin users. Check the latest studies of Robitussin.

On Jul, 19, 2026

27 people who take Desyrel and Robitussin together, and have interactions are studied.

Desyrel and Robitussin drug interactions.

What are the common drug interactions of Desyrel and Robitussin, by gender? *:

female:

Pain
Peripheral swelling
Pulmonary hypertension (increase in blood pressure in the lung artery)
Rhinorrhoea (watery mucus discharge from the nose)
Sinusitis (inflammation of sinus)
Sluggishness (lacking alertness)
Thrombocytopenia (decrease of platelets in blood)
Upper respiratory tract infection bacterial
Viral upper respiratory tract infection
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

male:

Fall
Anaemia postoperative
Death
Dysphagia (a condition in which swallowing is difficult or painful)
Emotional distress
Fear
Femoral neck fracture (neck of femur bone fracture)
General physical health deterioration (weak health status)
Haemorrhagic cyst (bleeding cyst)
Hospitalisation

What are the common drug interactions of Desyrel and Robitussin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Agitation (state of anxiety or nervous excitement)
Anaemia (lack of blood)
Anxiety
Aspartate aminotransferase increased
Blood bilirubin increased
Cough
Decreased appetite
Fatigue (feeling of tiredness)
Febrile neutropenia (fever with reduced white blood cells)
Haemoglobin decreased

20-29:

Pneumonia

30-39:

n/a

40-49:

n/a

50-59:

Acute respiratory failure
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Cellulitis (infection under the skin)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Corona virus infection (infection caused by a corona virus)
Dyspnoea (difficult or laboured respiration)
Hypokalaemia (low potassium)
Productive cough
Rhinovirus infection
Sputum discoloured

60+:

Back pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Drug hypersensitivity
Dyspnoea (difficult or laboured respiration)
Eye irritation
Fall
Femoral neck fracture (neck of femur bone fracture)
General physical health deterioration (weak health status)
Haemorrhagic cyst (bleeding cyst)
Headache (pain in head)

What are the existing conditions these people have? *

Pain: 12 people, 44.44%
Cough: 9 people, 33.33%
Sleep Disorder: 8 people, 29.63%
Wheezing (a high-pitched whistling sound made while you breath): 6 people, 22.22%
Stress And Anxiety: 6 people, 22.22%
Depression: 6 people, 22.22%
Dyspnea (difficult or laboured breathing): 6 people, 22.22%
Nausea And Vomiting: 4 people, 14.81%
Constipation: 4 people, 14.81%
High Blood Pressure: 4 people, 14.81%

* Approximation only. Some reports may have incomplete information.

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