Dexedrine and Cannabis drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dexedrine (dextroamphetamine sulfate) and Cannabis (marijuana). Common drug interactions include fatigue among females and hereditary angioedema among males.

The phase IV clinical study analyzes what interactions people have when they take Dexedrine and Cannabis. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Dexedrine?

Dexedrine has active ingredients of dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 4,735 Dexedrine users. Check the latest studies of Dexedrine.

What is Cannabis?

Cannabis has active ingredients of marijuana. It is often used in stress and anxiety. eHealthMe is studying from 13,371 Cannabis users. Check the latest studies of Cannabis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

21 people who take Dexedrine and Cannabis together, and have interactions are studied.

Dexedrine and Cannabis drug interactions.

What are the common drug interactions of Dexedrine and Cannabis, by gender? *:

female:

Fatigue (feeling of tiredness)
Urinary tract infection
Malaise (a feeling of general discomfort or uneasiness)
Cataplexy (loss of muscle tone accompanied by full conscious awareness)
Colonoscopy
Decreased appetite
Dyspnoea (difficult or laboured respiration)
Fibromyalgia (a long-term condition which causes pain all over the body)
Food allergy
Hunger

male:

Hereditary angioedema (recurrent episodes of severe swelling)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Pain in extremity
Palpitations (feelings or sensations that your heart is pounding or racing)
Sensory loss (senses loss)
Fibrin d dimer increased
Fibromyalgia (a long-term condition which causes pain all over the body)
Pericarditis (inflammation of the pericardium)
Polyp
Weight increased

What are the common drug interactions of Dexedrine and Cannabis, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Cataplexy (loss of muscle tone accompanied by full conscious awareness)
Colonoscopy
Decreased appetite
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Fibromyalgia (a long-term condition which causes pain all over the body)
Food allergy
Hunger
Hypertension (high blood pressure)
Hypopnoea (decrease in the breathing rate)

40-49:

Fatigue (feeling of tiredness)
Kidney infection
Micturition urgency (urgency to pass the urine)
Nasopharyngitis (inflammation of the nasopharynx)
Systemic mycosis (fungal infections of the body)
Urinary retention (the inability to completely or partially empty the bladder)
Urinary tract infection
Cystitis (inflammation of the wall of the bladder)
Fungal infection
Bladder disorder

50-59:

Hereditary angioedema (recurrent episodes of severe swelling)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Pain in extremity
Palpitations (feelings or sensations that your heart is pounding or racing)
Sensory loss (senses loss)
Fibrin d dimer increased
Fibromyalgia (a long-term condition which causes pain all over the body)
Pericarditis (inflammation of the pericardium)
Polyp
Drug ineffective

60+:

n/a

What are the existing conditions these people have? *

Hereditary Angioedema (recurrent episodes of severe swelling): 7 people, 33.33%
High Blood Pressure: 4 people, 19.05%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 19.05%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 3 people, 14.29%
Neuralgia (pain in one or more nerves): 3 people, 14.29%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 14.29%
Depression: 3 people, 14.29%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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