Dexedrine and Oxycodone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dexedrine (dextroamphetamine sulfate) and Oxycodone (oxycodone hydrochloride). Common drug interactions include muscle spasms among females and somnolence among males.

The phase IV clinical study analyzes what interactions people have when they take Dexedrine and Oxycodone. It is created by eHealthMe based on reports of 80 people who take the same drugs from the FDA, and is updated regularly.

What is Dexedrine?

Dexedrine has active ingredients of dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 4,735 Dexedrine users. Check the latest studies of Dexedrine.

What is Oxycodone?

Oxycodone has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 162,592 Oxycodone users. Check the latest studies of Oxycodone.

On Jul, 26, 2026

80 people who take Dexedrine and Oxycodone together, and have interactions are studied.

Dexedrine and Oxycodone drug interactions.

What are the common drug interactions of Dexedrine and Oxycodone, by gender? *:

female:

Muscle spasms (muscle contraction)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Radiculopathy (a set of conditions in which one or more nerves is affected and does not work properly)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Suicidal ideation
Bone disorder
Cervical dysplasia (abnormal changes in the cells on the surface of the cervix)
Cervix carcinoma (cancer of cervix)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)

male:

Somnolence (a state of near-sleep, a strong desire for sleep)
Gout (uric acid crystals building up in the body)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Therapeutic response decreased (less preventive response)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Urinary retention (the inability to completely or partially empty the bladder)
Urinary tract disorder
Neuropathy peripheral (surface nerve damage)
Arthropathy
Drug ineffective

What are the common drug interactions of Dexedrine and Oxycodone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Surgery
Blood sodium decreased
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Injection site abscess
Rapid correction of hyponatraemia (rapid correction of abnormally low concentrations of sodium ions in the circulating blood)
Staphylococcal infection (an infection with staphylococcus bacteria)

30-39:

Neuropathy peripheral (surface nerve damage)
Injury
Anxiety
Arthralgia (joint pain)
Bone disorder
Cervical dysplasia (abnormal changes in the cells on the surface of the cervix)
Cervix carcinoma (cancer of cervix)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Diarrhoea

40-49:

Anxiety
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Bone density decreased
Chronic kidney disease
Clavicle fracture
Contrast media allergy (reaction associated with the use of intravenous contrast material during radiology)
Diplopia (double vision)
Disability
Dizziness
Dyspnoea (difficult or laboured respiration)

50-59:

Diarrhoea
Drug ineffective
Abdominal discomfort
Arthralgia (joint pain)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Euphoric mood (excessively happy but may become angry or irritable)
Fall
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Knee arthroplasty
Labile hypertension (wildly fluctuating blood pressure)

60+:

Arthralgia (joint pain)
Weight increased
Urinary retention (the inability to completely or partially empty the bladder)
Urinary tract disorder
Drug ineffective
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Vomiting
Anaemia (lack of blood)
Anxiety

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 39 people, 48.75%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 31 people, 38.75%
Sleep Apnea Syndrome: 15 people, 18.75%
Drowsiness: 15 people, 18.75%
Metastases To Bone (cancer spreads to bone): 6 people, 7.50%
Bone Density Decreased: 5 people, 6.25%
Bone Loss: 4 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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