Diclofenac potassium and Spiriva drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diclofenac potassium (diclofenac potassium) and Spiriva (tiotropium bromide monohydrate). Common drug interactions include fall among females and bronchitis among males.

The phase IV clinical study analyzes what interactions people have when they take Diclofenac potassium and Spiriva. It is created by eHealthMe based on reports of 94 people who take the same drugs from the FDA, and is updated regularly.

What is Diclofenac potassium?

Diclofenac potassium has active ingredients of diclofenac potassium. It is often used in pain. eHealthMe is studying from 6,111 Diclofenac potassium users. Check the latest studies of Diclofenac potassium.

What is Spiriva?

Spiriva has active ingredients of tiotropium bromide monohydrate. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 156,666 Spiriva users. Check the latest studies of Spiriva.



On Jul, 14, 2026

94 people who take Diclofenac potassium and Spiriva together, and have interactions are studied.

Diclofenac potassium and Spiriva drug interactions.

What are the common drug interactions of Diclofenac Potassium and Spiriva, by gender? *:

female:

  1. Fall
  2. Fluid retention (an abnormal accumulation of fluid in the blood)
  3. Oral candidiasis (fungal infection of mouth)
  4. Stress
  5. Suicidal ideation
  6. Arthralgia (joint pain)
  7. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  8. Bone density decreased
  9. Cellulitis (infection under the skin)
  10. Chills (felling of cold)

male:

  1. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  2. Drug ineffective
  3. Obstructive airways disorder (a progressive disease that makes it hard to breathe)
  4. Diarrhoea
  5. Fatigue (feeling of tiredness)
  6. Colitis (inflammation of colon)
  7. Fall
  8. Nausea (feeling of having an urge to vomit)
  9. Arthralgia (joint pain)
  10. Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)

What are the common drug interactions of Diclofenac Potassium and Spiriva, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Pulmonary function test decreased

30-39:

n/a

40-49:

  1. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  2. Dyspnoea (difficult or laboured respiration)
  3. Ear infection
  4. Respiratory tract infection
  5. Wheezing (a high-pitched whistling sound made while you breath)
  6. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  7. Anxiety
  8. Arthralgia (joint pain)
  9. Bone density decreased
  10. Chills (felling of cold)

50-59:

  1. Retching (strong involuntary effort to vomit)
  2. Skin discolouration (change of skin colour)
  3. Tuberculosis (a bacterial infection by mycobacterium tuberculosis)
  4. Drug ineffective
  5. Peripheral swelling
  6. Stress
  7. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  8. Blood potassium decreased
  9. Blood pressure increased
  10. Bruxism (habitual grinding of the teeth, typically during sleep)

60+:

  1. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  2. Cardiac disorder
  3. Obstructive airways disorder (a progressive disease that makes it hard to breathe)
  4. Fall
  5. Nausea (feeling of having an urge to vomit)
  6. Diarrhoea
  7. Dizziness
  8. Fatigue (feeling of tiredness)
  9. Neck pain
  10. Arthralgia (joint pain)

What are the existing conditions these people have? *

  1. Arthritis (form of joint disorder that involves inflammation of one or more joints): 21 people, 22.34%
  2. Asthma: 19 people, 20.21%
  3. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 18 people, 19.15%
  4. Sleep Disorder: 17 people, 18.09%
  5. Nausea (feeling of having an urge to vomit): 17 people, 18.09%
  6. Muscle Spasms (muscle contraction): 17 people, 18.09%
  7. Hypercalcaemia (elevated calcium (ca+) level in the blood): 17 people, 18.09%
  8. Depression: 17 people, 18.09%
  9. Immunodeficiency Common Variable: 12 people, 12.77%
  10. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 8.51%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Diclofenac potassium and Spiriva:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Diclofenac potassium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Spiriva:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Diclofenac potassium and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Spiriva and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on diclofenac potassium and tiotropium bromide monohydrate (the active ingredients of Diclofenac potassium and Spiriva, respectively), and Diclofenac potassium and Spiriva (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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