Dificid and Protonix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dificid (fidaxomicin) and Protonix (pantoprazole sodium). Common drug interactions include renal failure among females and adverse event among males.

The phase IV clinical study analyzes what interactions people have when they take Dificid and Protonix. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Dificid?

Dificid has active ingredients of fidaxomicin. It is often used in clostridium difficile colitis. eHealthMe is studying from 1,295 Dificid users. Check the latest studies of Dificid.

What is Protonix?

Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 132,658 Protonix users. Check the latest studies of Protonix.

On Jul, 17, 2026

28 people who take Dificid and Protonix together, and have interactions are studied.

What are the common drug interactions of Dificid and Protonix, by gender? *:

female:

Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Respiratory failure (inadequate gas exchange by the respiratory system)
Respiratory tract infection
Respiratory tract infection fungal
Scedosporium infection (a filamentous fungus which occasionally causes infections in humans)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Vomiting
Diarrhoea
Pneumonia

male:

Adverse event
Cardiac arrest
Back pain
Bladder spasm
Chills (felling of cold)
Death
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Device related infection
Diarrhoea
Dizziness

What are the common drug interactions of Dificid and Protonix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Kidney infection
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pneumonia
Throat irritation
Weight fluctuation
Drug administration error
Clostridium test positive

50-59:

Drug ineffective
Hypertension (high blood pressure)
Cardiac arrest
Chronic kidney disease
Diarrhoea
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Ischaemic cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease)
Renal failure (kidney dysfunction)
Allergy to animal
Anaemia (lack of blood)

60+:

Adverse event
Diarrhoea
Death
Device related infection
Fall
Flatulence (flatus expelled through the anus)
Hyperhidrosis (abnormally increased sweating)
Impaired driving ability
Ocular hyperaemia (an abnormally large amount of blood in eye)
Ocular toxicity (damages eye)

What are the existing conditions these people have? *

Pain: 4 people, 14.29%
Depression: 3 people, 10.71%
Asthma: 3 people, 10.71%
Insomnia (sleeplessness): 3 people, 10.71%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 10.71%
Stress And Anxiety: 3 people, 10.71%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 7.14%
Blood Glucose Decreased: 2 people, 7.14%
Clostridial Infection (infectious conditions by clostridium bacteria): 2 people, 7.14%
Colitis (inflammation of colon): 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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