Digoxin and Topotecan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Digoxin (digoxin) and Topotecan (topotecan hydrochloride). Common drug interactions include neutropenia among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Digoxin and Topotecan. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Digoxin?

Digoxin has active ingredients of digoxin. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 93,740 Digoxin users. Check the latest studies of Digoxin.

What is Topotecan?

Topotecan has active ingredients of topotecan hydrochloride. eHealthMe is studying from 5,853 Topotecan users. Check the latest studies of Topotecan.

On Jul, 10, 2026

16 people who take Digoxin and Topotecan together, and have interactions are studied.

Digoxin and Topotecan drug interactions.

What are the common drug interactions of Digoxin and Topotecan, by gender? *:

female:

Neutropenia (an abnormally low number of neutrophils)
Diarrhoea
Death
Fatigue (feeling of tiredness)
Herpes zoster
Hypoaesthesia (reduced sense of touch or sensation)
Lymphadenopathy (disease or enlargement of lymph nodes)
Pneumonia
Productive cough
Rash pruritic (redness with itching)

male:

Diarrhoea
Neutropenia (an abnormally low number of neutrophils)
Bone marrow failure
Cardiac failure
Intestinal obstruction
Anaemia (lack of blood)
Aortic aneurysm rupture (enlarged aortic artery rapture caused by a weakening of the artery wall)
Appendicitis (inflammation of the appendix)
Appetite decreased (decreased appetite occurs when you have a reduced desire to eat)
Asbestosis (chronic lung disease caused by scarring of lung tissue, which stems from prolonged exposure to asbestos)

What are the common drug interactions of Digoxin and Topotecan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Drug toxicity
Fungaemia (fungi circulate in the blood)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypoxia (low oxygen in tissues)
Multi-organ failure (multisystem organ failure)
Neutropenia (an abnormally low number of neutrophils)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Sepsis (a severe blood infection that can lead to organ failure and death)
Venous thrombosis deep limb (blood clot that forms in a vein deep in the limb)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Diarrhoea
Neutropenia (an abnormally low number of neutrophils)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Productive cough
Weight decreased
Back pain
Blood potassium increased
Renal failure (kidney dysfunction)
Abdominal discomfort
Alopecia (absence of hair from areas of the body)

What are the existing conditions these people have? *

High Blood Pressure: 3 people, 18.75%
Diarrhea: 3 people, 18.75%
Lung Cancer - Small Cell (lung cancer): 3 people, 18.75%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 3 people, 18.75%
Type 2 Diabetes: 2 people, 12.50%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 2 people, 12.50%
Abdominal Pain Upper: 2 people, 12.50%
Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 12.50%
Pain In Extremity: 2 people, 12.50%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 2 people, 12.50%

* Approximation only. Some reports may have incomplete information.

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