Dilantin and Aredia drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dilantin (phenytoin sodium) and Aredia (pamidronate disodium). Common drug interactions include hypoaesthesia among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Dilantin and Aredia. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.

What is Dilantin?

Dilantin has active ingredients of phenytoin sodium. It is often used in epilepsy. eHealthMe is studying from 20,859 Dilantin users. Check the latest studies of Dilantin.

What is Aredia?

Aredia has active ingredients of pamidronate disodium. It is often used in breast cancer. eHealthMe is studying from 15,365 Aredia users. Check the latest studies of Aredia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

57 people who take Dilantin and Aredia together, and have interactions are studied.

What are the common drug interactions of Dilantin and Aredia, by gender? *:

female:

Hypoaesthesia (reduced sense of touch or sensation)
Pain
Dyspnoea (difficult or laboured respiration)
Atelectasis (partial or complete collapse of the lung)
Back pain
Primary sequestrum (piece of dead bone that has become separated during the process of necrosis from normal/sound bone)
Spinal osteoarthritis (joint cartilage loss in spine)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Nausea (feeling of having an urge to vomit)
Scoliosis (a medical condition in which a person's spine is curved from side to side)

male:

Dyspnoea (difficult or laboured respiration)
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Device related infection
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Kyphosis (a condition of over-curvature of the thoracic vertebrae (upper back))

What are the common drug interactions of Dilantin and Aredia, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anticonvulsant drug level below therapeutic
Asthenia (weakness)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Fatigue (feeling of tiredness)
Metastases to central nervous system (cancer spreads to central nervous system)
Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
Dyspnoea (difficult or laboured respiration)
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)

40-49:

Atelectasis (partial or complete collapse of the lung)
Back pain
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dizziness
Dyspnoea (difficult or laboured respiration)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Neuropathy peripheral (surface nerve damage)

50-59:

Spinal osteoarthritis (joint cartilage loss in spine)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Bone disorder
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Intervertebral disc protrusion (spinal disc protrusion)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Onychomycosis (fungal infection of the nail)
Osteosclerosis (an elevation in bone density)
Rib fracture

60+:

Blood lactate dehydrogenase increased
Anaemia (lack of blood)
Blood creatinine increased
Bone disorder
Bone fissure
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bruxism (habitual grinding of the teeth, typically during sleep)
Cellulitis (infection under the skin)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Confusional state

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 14 people, 24.56%
Osteoporosis (bones weak and more likely to break): 11 people, 19.30%
Breast Cancer Metastatic: 11 people, 19.30%
Ovarian Cancer (cancer of ovary): 7 people, 12.28%
Neoplasm Malignant (cancer tumour): 7 people, 12.28%
Migraine (headache): 7 people, 12.28%
Hot Flush (sudden feelings of heat): 7 people, 12.28%
Discomfort: 7 people, 12.28%
Granulocyte Count Decreased: 6 people, 10.53%
Metastases To Bone (cancer spreads to bone): 3 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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