Dilantin and Codeine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dilantin (phenytoin sodium) and Codeine (codeine sulfate). Common drug interactions include somnolence among females and drug hypersensitivity among males.

The phase IV clinical study analyzes what interactions people have when they take Dilantin and Codeine. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Dilantin?

Dilantin has active ingredients of phenytoin sodium. It is often used in epilepsy. eHealthMe is studying from 20,858 Dilantin users. Check the latest studies of Dilantin.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,342 Codeine users. Check the latest studies of Codeine.

On Aug, 03, 2026

36 people who take Dilantin and Codeine together, and have interactions are studied.

What are the common drug interactions of Dilantin and Codeine, by gender? *:

female:

Somnolence (a state of near-sleep, a strong desire for sleep)
Confusional state
Contusion (a type of hematoma of tissue in which capillaries)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Headache (pain in head)
Malaise (a feeling of general discomfort or uneasiness)
Pneumonia
Pyrexia (fever)
Swollen tongue (swelling of tongue)
Agitation (state of anxiety or nervous excitement)

male:

Drug hypersensitivity
Angiopathy (generic term for a disease of the blood vessels)
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Drug screen positive
Overdose

What are the common drug interactions of Dilantin and Codeine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Drug hypersensitivity
Abdominal pain
Aldolase increased
Biliary dilatation
Blood cholesterol increased
C1 esterase inhibitor decreased
Cavernous sinus thrombosis (formation of a blood clot in brain)
Cellulitis (infection under the skin)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain

40-49:

Road traffic accident
Schizophrenia (a mental disorder characterized by a breakdown of thought processes)
Sensory loss (senses loss)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Skin discolouration (change of skin colour)
Sleep disorder
Somnolence (a state of near-sleep, a strong desire for sleep)
Speech disorder
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Suicidal ideation

50-59:

Drug hypersensitivity
Injection site erythema (redness at injection site)
Injection site swelling
Pleural effusion (water on the lungs)
Pneumonia

60+:

Drug hypersensitivity
Abdominal distension
Hypotension (abnormally low blood pressure)
Hypoxia (low oxygen in tissues)
Nausea (feeling of having an urge to vomit)
Peripheral coldness
Peripheral swelling
Pneumonia
Pyrexia (fever)
Sepsis (a severe blood infection that can lead to organ failure and death)

What are the existing conditions these people have? *

Constipation: 3 people, 8.33%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 5.56%
Nausea (feeling of having an urge to vomit): 2 people, 5.56%
High Blood Cholesterol: 2 people, 5.56%
Cough: 2 people, 5.56%
Blood Potassium Decreased: 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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