Dilantin and Excedrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dilantin (phenytoin sodium) and Excedrin (acetaminophen; aspirin; caffeine). Common drug interactions include abdominal pain lower among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Dilantin and Excedrin. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Dilantin?

Dilantin has active ingredients of phenytoin sodium. It is often used in epilepsy. eHealthMe is studying from 20,858 Dilantin users. Check the latest studies of Dilantin.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

On Jul, 18, 2026

26 people who take Dilantin and Excedrin together, and have interactions are studied.

Dilantin and Excedrin drug interactions.

What are the common drug interactions of Dilantin and Excedrin, by gender? *:

female:

Abdominal pain lower
Activities of daily living impaired
Altered state of consciousness (altered state of mind)
Back pain
Bipolar disorder (mood disorder)
Confusional state
Conversion disorder (neurological symptoms, such as numbness, blindness, paralysis, or fits without a definable organic cause)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)

male:

Fatigue (feeling of tiredness)
Hospitalisation
Autism (a mental condition, present from early childhood, characterized by difficulty in communicating and forming relationships with other people and in using language and abstract concepts)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dizziness
Drug exposure via breast milk
Ear infection
Eyelid ptosis (falling of the upper or lower eyelid)
Gallbladder disorder
Grand mal convulsion (a type of generalized seizure that affects the entire brain)

What are the common drug interactions of Dilantin and Excedrin, by age (0-1 to 60+)? *:

0-1:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Attention deficit/hyperactivity disorder
Autism (a mental condition, present from early childhood, characterized by difficulty in communicating and forming relationships with other people and in using language and abstract concepts)
Drug exposure via breast milk
Ear infection
Eyelid ptosis (falling of the upper or lower eyelid)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Hepatosplenomegaly neonatal (enlargement of both the liver and the spleen in neonatal)
Hyperbilirubinaemia neonatal (excess of bilirubin in the blood in newborn)
Moderate mental retardation (an intellectual disability that interferes with someone's intelligence and capacity for adaptive behaviour at a moderate level)

2-9:

n/a

10-19:

n/a

20-29:

Asthma
Cerebral venous thrombosis (clot in brains venous blood system)
Intracranial venous sinus thrombosis (presence of thrombosis (a blood clot) in the dural venous sinuses, which drain blood from the brain)
Pleuritic pain
Sinusitis (inflammation of sinus)
Transverse sinus thrombosis (a blood clot in transverse sinus)

30-39:

Abdominal pain lower
Altered state of consciousness (altered state of mind)
Back pain
Bipolar disorder (mood disorder)
Conversion disorder (neurological symptoms, such as numbness, blindness, paralysis, or fits without a definable organic cause)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Herpes simplex (herpes simplex is a common viral infection)
Injury
Lymphadenopathy (disease or enlargement of lymph nodes)

40-49:

Fatigue (feeling of tiredness)
Pneumonia
Adverse drug reaction
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cervix carcinoma (cancer of cervix)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Depressed level of consciousness
Emotional distress
Gallbladder disorder
Influenza

50-59:

Drug abuser
Drug hypersensitivity
Nausea (feeling of having an urge to vomit)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Rash pruritic (redness with itching)

60+:

Fatigue (feeling of tiredness)
Activities of daily living impaired
Drug ineffective
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Weight increased
Arrhythmia (irregular heartbeat)
Blood alkaline phosphatase increased
Blood osmolarity increased
Diarrhoea
Disease progression

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 4 people, 15.38%
Migraine (headache): 4 people, 15.38%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 4 people, 15.38%
Stress And Anxiety: 3 people, 11.54%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 11.54%
Insomnia (sleeplessness): 3 people, 11.54%
Depression: 3 people, 11.54%
Bipolar Disorder (mood disorder): 3 people, 11.54%
Immunodeficiency Common Variable: 2 people, 7.69%
High Blood Pressure: 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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