Dilantin and Levofloxacin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dilantin (phenytoin sodium) and Levofloxacin (levofloxacin; sodium chloride). Common drug interactions include escherichia infection among females and dermatitis exfoliative among males.

The phase IV clinical study analyzes what interactions people have when they take Dilantin and Levofloxacin. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Dilantin?

Dilantin has active ingredients of phenytoin sodium. It is often used in epilepsy. eHealthMe is studying from 20,858 Dilantin users. Check the latest studies of Dilantin.

What is Levofloxacin?

Levofloxacin has active ingredients of levofloxacin; sodium chloride. It is often used in sinusitis. eHealthMe is studying from 16,335 Levofloxacin users. Check the latest studies of Levofloxacin.

On Aug, 13, 2026

58 people who take Dilantin and Levofloxacin together, and have interactions are studied.

Dilantin and Levofloxacin drug interactions.

What are the common drug interactions of Dilantin and Levofloxacin, by gender? *:

female:

Escherichia infection (bacterial infection by escherichia coli)
Fall
Renal cyst (kidney cyst)
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arteriosclerosis (thickening and hardening of arteries)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Back pain
Blood creatinine increased

male:

Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)
Alanine aminotransferase increased
Blood alkaline phosphatase increased
Blood chloride decreased
Blood lactate dehydrogenase increased
Blood potassium decreased
Blood sodium decreased
Blood triglycerides increased
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

What are the common drug interactions of Dilantin and Levofloxacin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cerebral infarction (less blood supply to brain resulting tissue damage)
Pyrexia (fever)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Hepatic trauma (liver injury)
Hepatitis (inflammation of the liver)
Hepatotoxicity (chemical-driven liver damage)
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Neutropenia (an abnormally low number of neutrophils)

30-39:

Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)
Dry skin
Flushing (the warm, red condition of human skin)
Pneumonia pneumococcal (pneumococcal pneumonia is a common but serious infection and inflammation of the lungs)
Pneumonia streptococcal (pneumonia, caused by streptococcus pneumoniae)
Rigors (an episode of shaking or exaggerated shivering)
Sepsis (a severe blood infection that can lead to organ failure and death)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Toxic shock syndrome (a rare but serious medical condition caused by a bacterial infection)

40-49:

Diaphragmatic paralysis (acquired dysfunction of the phrenic nerve)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Hepatitis (inflammation of the liver)
Lethargy (tiredness)
Body temperature increased
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Fatigue (feeling of tiredness)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)

50-59:

Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaemia (lack of blood)
Anxiety
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Aphthous stomatitis (mouth ulcer)
Arteriosclerosis (thickening and hardening of arteries)
Asthma
Atelectasis (partial or complete collapse of the lung)

60+:

Anaemia (lack of blood)
Blood lactate dehydrogenase increased
Arteriosclerosis (thickening and hardening of arteries)
Atelectasis (partial or complete collapse of the lung)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Back pain
Blood creatinine increased
Bone disorder
Bone fissure
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

What are the existing conditions these people have? *

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 9 people, 15.52%
High Blood Cholesterol: 4 people, 6.90%
Pneumonia: 3 people, 5.17%
Pharyngitis (inflammation of the pharynx, causing a sore throat): 3 people, 5.17%
Constipation: 3 people, 5.17%

* Approximation only. Some reports may have incomplete information.

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