Dilantin and Meridia drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dilantin (phenytoin sodium) and Meridia (sibutramine hydrochloride). Common drug interactions include convulsions among females and convulsion among males.

The phase IV clinical study analyzes what interactions people have when they take Dilantin and Meridia. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Dilantin?

Dilantin has active ingredients of phenytoin sodium. It is often used in epilepsy. eHealthMe is studying from 20,859 Dilantin users. Check the latest studies of Dilantin.

What is Meridia?

Meridia has active ingredients of sibutramine hydrochloride. It is often used in weight loss. eHealthMe is studying from 6,939 Meridia users. Check the latest studies of Meridia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

14 people who take Dilantin and Meridia together, and have interactions are studied.

What are the common drug interactions of Dilantin and Meridia, by gender? *:

female:

Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Crying
Drug hypersensitivity
Fatigue (feeling of tiredness)
Febrile convulsion (a convulsion associated with a significant rise in body temperature)
Head injury
Hypersensitivity
Hypoaesthesia (reduced sense of touch or sensation)
Influenza like illness
Loose stools

male:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Sexual dysfunction (difficulty experienced by an individual or a couple during any stage of a normal sexual activity)

What are the common drug interactions of Dilantin and Meridia, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Headache (pain in head)
Pyrexia (fever)
Accident
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Drug hypersensitivity
Febrile convulsion (a convulsion associated with a significant rise in body temperature)
Head injury
Hypersensitivity
Swelling

20-29:

n/a

30-39:

Thirst
Unexpected therapeutic effect
Loose stools
Sexual dysfunction (difficulty experienced by an individual or a couple during any stage of a normal sexual activity)

40-49:

Influenza like illness

50-59:

Appetite increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Crying
Fatigue (feeling of tiredness)
Hypoaesthesia (reduced sense of touch or sensation)
Myalgia (muscle pain)

60+:

Headache (pain in head)

* Approximation only. Some reports may have incomplete information.

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