Diphen and Amifostine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Amifostine (amifostine). Common drug interactions include gastroenteritis among females and bone marrow failure among males.

The phase IV clinical study analyzes what interactions people have when they take Diphen and Amifostine. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Amifostine?

Amifostine has active ingredients of amifostine. eHealthMe is studying from 425 Amifostine users. Check the latest studies of Amifostine.

On Jul, 12, 2026

23 people who take Diphen and Amifostine together, and have interactions are studied.

Diphen and Amifostine drug interactions.

What are the common drug interactions of Diphen and Amifostine, by gender? *:

female:

Gastroenteritis (inflammation of stomach and intestine)
Chest discomfort
Dyspnoea (difficult or laboured respiration)
Anaemia (lack of blood)
Anaphylactic reaction (serious allergic reaction)
Anorectal infection
Constipation
Gasping (laboured breathing)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Platelet count decreased

male:

Bone marrow failure
Cerebral infarction (less blood supply to brain resulting tissue damage)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Mucosal inflammation (infection of mucous membrane)
Sweating increased (excess sweating)
Thrombocytopenia (decrease of platelets in blood)
Lung infection
Ventricular extrasystoles (premature cardiac contraction)
Abdominal pain
Arrhythmia (irregular heartbeat)

What are the common drug interactions of Diphen and Amifostine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Gastroenteritis (inflammation of stomach and intestine)
Dyspnoea (difficult or laboured respiration)
Flushing (the warm, red condition of human skin)
Abdominal pain
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Mucosal inflammation (infection of mucous membrane)
Sweating increased (excess sweating)
Vomiting

50-59:

Chest discomfort
Anaphylactic reaction (serious allergic reaction)
Dyspnoea (difficult or laboured respiration)
Gasping (laboured breathing)
Asphyxia (a condition in which there is an extreme decrease in the concentration of oxygen in the body)
Burning sensation
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Chest pain
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Hypersensitivity

60+:

Bone marrow failure
Cerebral infarction (less blood supply to brain resulting tissue damage)
Myelosuppression (a decrease in the production of blood cells)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Thrombocytopenia (decrease of platelets in blood)
White blood cell count decreased
Anaemia (lack of blood)
Anorectal infection
Constipation
Haemorrhoids (a swollen vein or group of veins in the region of the anus)

What are the existing conditions these people have? *

Reduction Of Increased Intracranial Pressure (reducing intracranial pressure): 3 people, 13.04%
Urination - Excessive Volume: 2 people, 8.70%
Ovarian Epithelial Cancer (cancer that begins in the cells on the surface of the ovary): 2 people, 8.70%
Lung Cancer - Non-Small Cell (lung cancer): 2 people, 8.70%
Leukopenia (less number of white blood cells in blood): 2 people, 8.70%
Hypoaesthesia (reduced sense of touch or sensation): 2 people, 8.70%
High Blood Pressure: 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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