Diphen and Arg drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Arg (l - arginine). Common drug interactions include upper respiratory tract infection among females and bursitis infective among males.

The phase IV clinical study analyzes what interactions people have when they take Diphen and Arg. It is created by eHealthMe based on reports of 69 people who take the same drugs from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Arg?

Arg has active ingredients of l - arginine. eHealthMe is studying from 2,666 Arg users. Check the latest studies of Arg.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

69 people who take Diphen and Arg together, and have interactions are studied.

What are the common drug interactions of Diphen and Arg, by gender? *:

female:

Upper respiratory tract infection
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Haemorrhage (bleeding)
Influenza
Pain in extremity
Breast cancer
Cystitis (inflammation of the wall of the bladder)
Food allergy
Infusion site erythema (reddening of the skin at infusion site)
Pneumonia

male:

Bursitis infective (the bursa can become infected, this is called infected bursitis)
Cellulitis (infection under the skin)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Drug ineffective
Gait disturbance
Hospitalisation
Hunger
Hypoaesthesia (reduced sense of touch or sensation)
Influenza
Pain

What are the common drug interactions of Diphen and Arg, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Tooth loss
Urogenital disorder
Victim of crime
Weight decreased
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Malaise (a feeling of general discomfort or uneasiness)
Weight increased
Back pain
Influenza

40-49:

Colitis (inflammation of colon)
Enteritis (inflammation of the small intestine)
Small intestinal obstruction (blockage in small intestine)

50-59:

Bursitis infective (the bursa can become infected, this is called infected bursitis)
Cellulitis (infection under the skin)
Headache (pain in head)
Fatigue (feeling of tiredness)
Gait disturbance
Hypoaesthesia (reduced sense of touch or sensation)
Peroneal nerve palsy
Abdominal discomfort
Alopecia (absence of hair from areas of the body)
Asthenia (weakness)

60+:

Fatigue (feeling of tiredness)
Leukopenia (less number of white blood cells in blood)
Infusion site pain
Infusion site pruritus (severe itching at infusion site)
Infusion site reaction
Multiple allergies (allergy to multiple agents)
Rectal haemorrhage (bleeding from anus)
Sinusitis (inflammation of sinus)
Abdominal discomfort
Abdominal distension

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 28 people, 40.58%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 20.29%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 7.25%
Immunodeficiency: 4 people, 5.80%
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood): 4 people, 5.80%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 4 people, 5.80%
Chronic Inflammatory Demyelinating Polyradiculoneuropathy (long lasting infection of nerves outside brain and spinal cord): 4 people, 5.80%

* Approximation only. Some reports may have incomplete information.

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