Diphen and Asparlas drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Asparlas (calaspargase pegol-mknl). Common drug interactions include pancreatitis among females and cardio-respiratory arrest among males.

The phase IV clinical study analyzes what interactions people have when they take Diphen and Asparlas. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Asparlas?

Asparlas has active ingredients of calaspargase pegol-mknl. eHealthMe is studying from 269 Asparlas users. Check the latest studies of Asparlas.



On Jul, 13, 2026

19 people who take Diphen and Asparlas together, and have interactions are studied.

Diphen and Asparlas drug interactions.

What are the common drug interactions of Diphen and Asparlas, by gender? *:

female:

  1. Pancreatitis (inflammation of pancreas)
  2. Tachypnoea (a condition of rapid breathing over 20 per minute)

male:

  1. Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
  2. Chest discomfort
  3. Dyspnoea (difficult or laboured respiration)
  4. Hypersensitivity
  5. Vomiting
  6. Wheezing (a high-pitched whistling sound made while you breath)

What are the common drug interactions of Diphen and Asparlas, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
  2. Chest discomfort
  3. Dyspnoea (difficult or laboured respiration)
  4. Hypersensitivity
  5. Pancreatitis (inflammation of pancreas)
  6. Tachypnoea (a condition of rapid breathing over 20 per minute)
  7. Vomiting
  8. Wheezing (a high-pitched whistling sound made while you breath)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

  1. Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 7 people, 36.84%
  2. B-Cell Type Acute Leukaemia (cancer of the white blood cells): 6 people, 31.58%
  3. Leukaemia (blood or bone marrow cancer): 4 people, 21.05%
  4. High Blood Pressure: 1 person, 5.26%
  5. B Precursor Type Acute Leukaemia (lymphoid cancer): 1 person, 5.26%
  6. Acute Leukaemia (blood cancer): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Diphen and Asparlas?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Diphen and Asparlas:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Diphen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Asparlas:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Diphen and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Asparlas and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride and calaspargase pegol-mknl (the active ingredients of Diphen and Asparlas, respectively), and Diphen and Asparlas (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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