Diphen and Cinvanti drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Cinvanti (aprepitant). Common drug interactions include headache among females and febrile neutropenia among males.

The phase IV clinical study analyzes what interactions people have when they take Diphen and Cinvanti. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Cinvanti?

Cinvanti has active ingredients of aprepitant. eHealthMe is studying from 150 Cinvanti users. Check the latest studies of Cinvanti.

On Jul, 04, 2026

17 people who take Diphen and Cinvanti together, and have interactions are studied.

What are the common drug interactions of Diphen and Cinvanti, by gender? *:

female:

Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Infusion related reaction
Lethargy (tiredness)
Pain in jaw
Neutropenic colitis (inflammation of the cecum, often with involvement of the ascending colon and ileum, a life threatening condition)
Nausea (feeling of having an urge to vomit)
Vomiting
Febrile neutropenia (fever with reduced white blood cells)
Abdominal pain

male:

Febrile neutropenia (fever with reduced white blood cells)
Pneumonia

What are the common drug interactions of Diphen and Cinvanti, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Nausea (feeling of having an urge to vomit)
Vomiting

50-59:

Nausea (feeling of having an urge to vomit)
Vomiting

60+:

Neutropenic colitis (inflammation of the cecum, often with involvement of the ascending colon and ileum, a life threatening condition)
Febrile neutropenia (fever with reduced white blood cells)
Pain in jaw
Pneumonia
Abdominal pain
Dyspnoea (difficult or laboured respiration)
Flushing (the warm, red condition of human skin)
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Infusion related reaction

What are the existing conditions these people have? *

Burkitt Lymphoma (cancer of the lymphatic system): 4 people, 23.53%
Nausea (feeling of having an urge to vomit): 3 people, 17.65%
Hypokalemia (low potassium): 3 people, 17.65%
Febrile Neutropenia (fever with reduced white blood cells): 2 people, 11.76%
High Blood Pressure: 2 people, 11.76%
Pulmonary Embolism (blockage of the main artery of the lung): 2 people, 11.76%
Hypersensitivity: 2 people, 11.76%
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood): 2 people, 11.76%
Dehydration (dryness resulting from the removal of water): 2 people, 11.76%
Endometrial Cancer: 2 people, 11.76%

* Approximation only. Some reports may have incomplete information.

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