Diphen and Cleocin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Cleocin (clindamycin phosphate). Common drug interactions include hypoxia among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Diphen and Cleocin. It is created by eHealthMe based on reports of 92 people who take the same drugs from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Cleocin?

Cleocin has active ingredients of clindamycin phosphate. It is often used in infection. eHealthMe is studying from 3,940 Cleocin users. Check the latest studies of Cleocin.

On Jul, 23, 2026

92 people who take Diphen and Cleocin together, and have interactions are studied.

What are the common drug interactions of Diphen and Cleocin, by gender? *:

female:

Hypoxia (low oxygen in tissues)
Intervertebral disc degeneration (spinal disc degeneration)
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Osteitis (a general term for inflammation of bone)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Rash
Renal failure chronic (long lasting kidney dysfunction)
Skin disorder (skin disease)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Spinal osteoarthritis (joint cartilage loss in spine)

male:

Chronic kidney disease
Proctalgia (pain in the rectum)
Rectal abscess (pus in rectum)
Septic shock (shock due to blood infection)
Blood creatinine increased
Diabetic complication
Muscular weakness (muscle weakness)
Pneumonia
Pyrexia (fever)
Seasonal allergy (allergic condition due to certain season)

What are the common drug interactions of Diphen and Cleocin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Chest pain
Dyspnoea (difficult or laboured respiration)
Ear pain
Fatigue (feeling of tiredness)
Gastric disorder (disease of stomach)
Infusion site pain
Infusion site scar
Malaise (a feeling of general discomfort or uneasiness)
Myalgia (muscle pain)
Oropharyngeal pain

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Compulsive sexual behaviour (unable to manage his/her sexual behaviour)
Compulsive shopping
Disability
Eating disorder
Emotional distress
Epistaxis (bleed from the nose)
Impulse-control disorder
Injury

40-49:

Anxiety
Depression
Dizziness
Fatigue (feeling of tiredness)
Hypotension (abnormally low blood pressure)
Tremor (trembling or shaking movements in one or more parts of your body)
Cellulitis (infection under the skin)
Sepsis (a severe blood infection that can lead to organ failure and death)
Blood glucose increased
Contusion (a type of hematoma of tissue in which capillaries)

50-59:

Respiratory disorder (respiratory disease)
Sinusitis (inflammation of sinus)
Vaginal infection
Weight increased
Folliculitis (infection of hair root)
Injection site bruising
Injection site erythema (redness at injection site)
Kidney infection
Leukaemia (blood or bone marrow cancer)
Lymphadenopathy (disease or enlargement of lymph nodes)

60+:

Proctalgia (pain in the rectum)
Nausea (feeling of having an urge to vomit)
Cellulitis (infection under the skin)
Chronic kidney disease
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Hypertension (high blood pressure)
Muscular weakness (muscle weakness)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Osteoporosis (bones weak and more likely to break)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 27 people, 29.35%
Pain: 14 people, 15.22%
Nausea (feeling of having an urge to vomit): 8 people, 8.70%
Lung Cancer - Non-Small Cell (lung cancer): 8 people, 8.70%
Nausea And Vomiting: 6 people, 6.52%
High Blood Pressure: 6 people, 6.52%
Rashes (redness): 5 people, 5.43%

* Approximation only. Some reports may have incomplete information.

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