Diphen and Cogentin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Cogentin (benztropine mesylate). Common drug interactions include hypertension among females and weight decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Diphen and Cogentin. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Cogentin?

Cogentin has active ingredients of benztropine mesylate. It is often used in tardive dyskinesia. eHealthMe is studying from 7,692 Cogentin users. Check the latest studies of Cogentin.

On Jul, 28, 2026

56 people who take Diphen and Cogentin together, and have interactions are studied.

What are the common drug interactions of Diphen and Cogentin, by gender? *:

female:

Hypertension (high blood pressure)
Multiple fractures
Multiple injuries
Muscle spasms (muscle contraction)
Myalgia (muscle pain)
Overdose
Pain in extremity
Pancreatitis (inflammation of pancreas)
Road traffic accident
Abdominal pain

male:

Weight decreased
Weight increased
Abnormal behaviour
Anger
Anxiety
Apathy
Asthenia (weakness)
Blood cholesterol increased
Blood glucose increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

What are the common drug interactions of Diphen and Cogentin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Weight decreased
Weight increased
Abnormal behaviour
Aggression
Anger
Apathy
Asthenia (weakness)
Blood cholesterol increased
Blood glucose increased
Delusion (a false belief or opinion)

30-39:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Abdominal pain
Anxiety
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Multiple fractures
Road traffic accident
Cellulitis (infection under the skin)
Hyperglycaemia (high blood sugar)
Oropharyngeal pain
Psychotic disorder

40-49:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Herpes zoster oticus (viral infection of the inner, middle, and external ear caused by varicella-zoster virus (vzv))
Infected cyst
Laceration (tearing of soft body tissue)
Loss of consciousness
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Multiple injuries
Muscle contractions involuntary (uncontrolled muscle contraction)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Nausea (feeling of having an urge to vomit)

50-59:

Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Fatigue (feeling of tiredness)
Hospitalisation
Increased appetite
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Neoplasm (tumour)
Stomatitis (inflammation of mucous membrane of mouth)
Tooth discolouration (a change in colour of teeth)
Weight increased

60+:

Intentional self-injury
Psychotic disorder
Breast cancer
Chest pain
Confusional state
Constipation
Contusion (a type of hematoma of tissue in which capillaries)
Cyclothymic disorder (mood disorder)
Decreased appetite
Delusion (a false belief or opinion)

What are the existing conditions these people have? *

Bipolar Disorder (mood disorder): 10 people, 17.86%
Stress And Anxiety: 8 people, 14.29%
Agitation (state of anxiety or nervous excitement): 6 people, 10.71%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 5 people, 8.93%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 5 people, 8.93%
Depression: 5 people, 8.93%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 5 people, 8.93%
Psychotic Disorder: 3 people, 5.36%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 5.36%
Extrapyramidal Disorder (involuntary muscle spasms in the face and neck): 3 people, 5.36%

* Approximation only. Some reports may have incomplete information.

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