Diphen and Cubicin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Cubicin (daptomycin). Common drug interactions include disseminated intravascular coagulation among females and chills among males.

The phase IV clinical study analyzes what interactions people have when they take Diphen and Cubicin. It is created by eHealthMe based on reports of 65 people who take the same drugs from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Cubicin?

Cubicin has active ingredients of daptomycin. It is often used in infection. eHealthMe is studying from 7,991 Cubicin users. Check the latest studies of Cubicin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 14, 2026

65 people who take Diphen and Cubicin together, and have interactions are studied.

What are the common drug interactions of Diphen and Cubicin, by gender? *:

female:

Disseminated intravascular coagulation (systemic activation of blood coagulation)
Drug toxicity
Fatigue (feeling of tiredness)
Glucose urine present
Hepatic congestion (liver congestion)
Hepatic failure (liver failure)
Hypotension (abnormally low blood pressure)
Ill-defined disorder
Influenza
International normalised ratio increased

male:

Chills (felling of cold)
Aortic valve disease
Disease recurrence
Drug ineffective
Endocarditis (inflammation in heart muscle)
Enterococcal infection
Pancreatitis (inflammation of pancreas)
Staphylococcal infection (an infection with staphylococcus bacteria)
Renal failure (kidney dysfunction)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)

What are the common drug interactions of Diphen and Cubicin, by age (0-1 to 60+)? *:

0-1:

Meningitis enterococcal (fungal inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)

2-9:

n/a

10-19:

Agitation (state of anxiety or nervous excitement)
Anaphylactic reaction (serious allergic reaction)
Blood calcium decreased
Blood glucose increased
Brain death
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Confusional state
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Drug toxicity

20-29:

International normalised ratio increased

30-39:

Aortic valve disease
Cardiac failure congestive
Cardiac valve disease (heart valve disease)
Cerebral artery embolism (sudden blocking of an artery by a clot or foreign material)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Coma (state of unconsciousness lasting more than six hours)
International normalised ratio increased
Kidney transplant rejection
Leukaemoid reaction (elevated white blood cell count, or leukocytosis, that is a physiological response to stress or infection)
Post procedural complication

40-49:

Swelling face
Visual acuity reduced (reduced clearness of vision)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Erythema (redness of the skin)
Haematocrit decreased
Haemoglobin decreased
Headache (pain in head)
Nausea (feeling of having an urge to vomit)

50-59:

Respiratory tract infection
Chills (felling of cold)
Influenza
International normalised ratio increased
Polyarthritis (arthritis which involves 5 or more joints simultaneously)
Rash
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Sinusitis (inflammation of sinus)
Fall
Muscle strain (an injury to a muscle in which the muscle fibres tear)

60+:

Blood creatinine increased
Aortic valve disease
Pancreatitis (inflammation of pancreas)
Pyrexia (fever)
Renal impairment (severely reduced kidney function)
Staphylococcal infection (an infection with staphylococcus bacteria)
Blood bilirubin increased
Blood creatine phosphokinase increased
Blood urea increased
Bone marrow failure

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 18 people, 27.69%
Nausea (feeling of having an urge to vomit): 10 people, 15.38%
Rashes (redness): 7 people, 10.77%
Oedema (fluid collection in tissue): 6 people, 9.23%
Proctalgia (pain in the rectum): 6 people, 9.23%
Osteomyelitis (infection of bone): 6 people, 9.23%
Febrile Neutropenia (fever with reduced white blood cells): 5 people, 7.69%
Hypocalcaemia (levels of calcium in blood serum are abnormally low): 5 people, 7.69%
Hypokalemia (low potassium): 5 people, 7.69%
Irritable Bowel Syndrome: 5 people, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Diphen and Cubicin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously