Diphen and Diflunisal drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Diflunisal (diflunisal). Common drug interactions include anhedonia among females and blood creatinine increased among males.

The phase IV clinical study analyzes what interactions people have when they take Diphen and Diflunisal. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Diflunisal?

Diflunisal has active ingredients of diflunisal. eHealthMe is studying from 945 Diflunisal users. Check the latest studies of Diflunisal.

On Jul, 15, 2026

24 people who take Diphen and Diflunisal together, and have interactions are studied.

Diphen and Diflunisal drug interactions.

What are the common drug interactions of Diphen and Diflunisal, by gender? *:

female:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Cellulitis (infection under the skin)
Emotional distress
Fatigue (feeling of tiredness)
Hypotension (abnormally low blood pressure)
Infusion related reaction
Loss of consciousness
Osteoporosis (bones weak and more likely to break)
Pain

male:

Blood creatinine increased
Decreased appetite
Gait disturbance
Nephrolithiasis (calculi in the kidneys)
Pain
Pneumonia
Drug ineffective
Dyspnoea exertional (breathlessness or shortness of breath)
Pericardial effusion (fluid around the heart)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

What are the common drug interactions of Diphen and Diflunisal, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Osteoporosis (bones weak and more likely to break)
Pain
Fracture
Lower limb fracture
Multiple fractures
Nightmare (unpleasant dream)

40-49:

Hypotension (abnormally low blood pressure)
Infusion related reaction
Loss of consciousness
Somnolence (a state of near-sleep, a strong desire for sleep)
Pruritus (severe itching of the skin)

50-59:

Fatigue (feeling of tiredness)
Hot flush (sudden feelings of heat)
Joint injury
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Abdominal distension
Arthralgia (joint pain)
Chronic kidney disease
Constipation

60+:

Blood creatinine increased
Cellulitis (infection under the skin)
Decreased appetite
Drug ineffective
Dyspnoea exertional (breathlessness or shortness of breath)
Pericardial effusion (fluid around the heart)

What are the existing conditions these people have? *

Hereditary Neuropathic Amyloidosis (hereditary- diseases resulting from abnormal deposition of certain proteins (amyloid) in various bodily areas by problems with signals from the nerves): 12 people, 50.00%
High Blood Pressure: 10 people, 41.67%
Erection Problems: 8 people, 33.33%
Diarrhea: 8 people, 33.33%
Neuralgia (pain in one or more nerves): 8 people, 33.33%
Nausea (feeling of having an urge to vomit): 6 people, 25.00%
Gastritis (inflammation of stomach): 6 people, 25.00%
Infection: 6 people, 25.00%
Enlarged Prostate: 6 people, 25.00%
Malignant Melanoma Stage Iii (cancer has spread to one or more lymph nodes): 6 people, 25.00%

* Approximation only. Some reports may have incomplete information.

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