Diphen and Elderberry drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Elderberry (american elder). Common drug interactions include nausea among females and appendicitis among males.

The phase IV clinical study analyzes what interactions people have when they take Diphen and Elderberry. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Elderberry?

Elderberry has active ingredients of american elder. eHealthMe is studying from 260 Elderberry users. Check the latest studies of Elderberry.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

12 people who take Diphen and Elderberry together, and have interactions are studied.

Diphen and Elderberry drug interactions.

What are the common drug interactions of Diphen and Elderberry, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Postural orthostatic tachycardia syndrome (abnormal increase in heart rate on becoming upright)
Pyrexia (fever)
Thyroid disorder (thyroid diseases)
Upper respiratory tract infection
Weight fluctuation
Cough
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Haemorrhage (bleeding)
Inflammation

male:

Appendicitis (inflammation of the appendix)
Urticaria (rash of round, red welts on the skin that itch intensely)

What are the common drug interactions of Diphen and Elderberry, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Infusion site pruritus (severe itching at infusion site)
Infusion site swelling
Injection site extravasation (flow of (blood or lymph) from injection site)
Injection site reaction
Migraine (headache)
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Pain
Postural orthostatic tachycardia syndrome (abnormal increase in heart rate on becoming upright)
Pyrexia (fever)

50-59:

Appendicitis (inflammation of the appendix)

60+:

Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 4 people, 33.33%
Primary Progressive Multiple Sclerosis (primary progressive inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 16.67%
Pneumonia: 2 people, 16.67%
Neurogenic Bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion): 2 people, 16.67%
Muscle Spasms (muscle contraction): 2 people, 16.67%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 16.67%
Influenza Like Illness: 2 people, 16.67%
Headache (pain in head): 2 people, 16.67%
Fever: 2 people, 16.67%
Fatigue (feeling of tiredness): 2 people, 16.67%

* Approximation only. Some reports may have incomplete information.

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