Diphen and Exforge drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Exforge (amlodipine besylate; valsartan). Common drug interactions include urinary tract infection among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Diphen and Exforge. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Exforge?

Exforge has active ingredients of amlodipine besylate; valsartan. It is often used in high blood pressure. eHealthMe is studying from 13,350 Exforge users. Check the latest studies of Exforge.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

38 people who take Diphen and Exforge together, and have interactions are studied.

What are the common drug interactions of Diphen and Exforge, by gender? *:

female:

Urinary tract infection
Diarrhoea
Sinusitis (inflammation of sinus)
Chronic kidney disease
Hypernatraemia (an abnormally high plasma concentration of sodium ions)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypervolaemia (abnormally increased volume of blood)
Malaise (a feeling of general discomfort or uneasiness)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)

male:

Pain
Arthralgia (joint pain)
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)
Type 2 diabetes mellitus
Urine output decreased
Vomiting
Chronic kidney disease
Febrile neutropenia (fever with reduced white blood cells)
Injection site extravasation (flow of (blood or lymph) from injection site)

What are the common drug interactions of Diphen and Exforge, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abscess limb (limb infection)
Cellulitis of male external genital organ (infection of male genitals soft tissue)
Chronic kidney disease
Hyperkalaemia (damage to or disease of the kidney)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Orchitis (inflammation of the testes)
Scrotal abscess (pus in scrotum)
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection

30-39:

n/a

40-49:

Headache (pain in head)
Pyrexia (fever)

50-59:

Febrile neutropenia (fever with reduced white blood cells)
Septic shock (shock due to blood infection)
Abdominal discomfort
Anaemia (lack of blood)
Arthralgia (joint pain)
Blood creatinine increased
Epigastric discomfort
Gastric ulcer (stomach ulcer)
Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)

60+:

Asthenia (weakness)
Hyperhidrosis (abnormally increased sweating)
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)
Type 2 diabetes mellitus
Urine output decreased
Vomiting
Upper respiratory tract infection
Chronic kidney disease
Injection site extravasation (flow of (blood or lymph) from injection site)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 19 people, 50.00%
High Blood Pressure: 10 people, 26.32%
Type 2 Diabetes: 4 people, 10.53%
Pain: 4 people, 10.53%
Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 10.53%
Rash Pruritic (redness with itching): 3 people, 7.89%
Constipation: 2 people, 5.26%
Diarrhea: 2 people, 5.26%
Fever: 2 people, 5.26%
Fluid Retention (an abnormal accumulation of fluid in the blood): 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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