Diphen and Fentanyl-100 drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Fentanyl-100 (fentanyl). Common drug interactions include convulsion among females and aspergillosis among males.

The phase IV clinical study analyzes what interactions people have when they take Diphen and Fentanyl-100. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Fentanyl-100?

Fentanyl-100 has active ingredients of fentanyl. It is often used in pain. eHealthMe is studying from 7,047 Fentanyl-100 users. Check the latest studies of Fentanyl-100.

On Jul, 12, 2026

20 people who take Diphen and Fentanyl-100 together, and have interactions are studied.

Diphen and Fentanyl-100 drug interactions.

What are the common drug interactions of Diphen and Fentanyl-100, by gender? *:

female:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cough
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Electrocardiogram st-t change
Emotional distress
Endocarditis bacterial (an inflammation of the inner layer of the heart by bacterial infection)
Extrasystoles

male:

Aspergillosis (an infection caused by a fungus called aspergillus)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Enterococcal infection
Hypotension (abnormally low blood pressure)
Ileus paralytic (obstruction of the intestine due to paralysis of the intestinal muscles)
Immunosuppression
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Multi-organ failure (multisystem organ failure)
Nephropathy (damage to or disease of a kidney)

What are the common drug interactions of Diphen and Fentanyl-100, by age (0-1 to 60+)? *:

0-1:

Hepatic failure (liver failure)
Immunosuppressant drug level increased
International normalised ratio increased
Liver injury

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pancreatic pseudocyst (collection of tissue and fluids that forms on pancreas)
Pancreatitis chronic (chronic inflammation of pancreas)

40-49:

Abdominal pain
Asthenia (weakness)
Blood pressure increased
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Facial palsy (paralysis of face nerve)
Heart rate increased
Herpes zoster
Hypotension (abnormally low blood pressure)
Incoherent (talking in a confused and unclear way)

50-59:

Angioedema (rapid swelling of the dermis)
Cardiac arrest
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Headache (pain in head)
Memory impairment
Pyrexia (fever)
Respiratory distress (difficulty in breathing)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

60+:

Aspergillosis (an infection caused by a fungus called aspergillus)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Cardiac arrest
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Coagulopathy (blood's ability to clot is impaired)
Depressed level of consciousness
Diastolic dysfunction
Drug toxicity
Enterococcal infection
Hypotension (abnormally low blood pressure)

What are the existing conditions these people have? *

Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 3 people, 15.00%
Nausea (feeling of having an urge to vomit): 2 people, 10.00%
High Blood Pressure: 2 people, 10.00%
Joint Pain: 2 people, 10.00%
Transient Ischaemic Attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 2 people, 10.00%
Leiomyosarcoma Metastatic (a very rare soft tissue sarcoma (cancer) that grows in muscle tissue spreading to other parts): 2 people, 10.00%
Neoplasm Malignant (cancer tumour): 1 person, 5.00%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 5.00%
Multiple Myeloma (cancer of the plasma cells): 1 person, 5.00%
Metastases To Lymph Nodes (cancer spreads to lymph node): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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