Diphen and Fentanyl transdermal system drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Fentanyl transdermal system (fentanyl). Common drug interactions include pneumonia among females and chest pain among males.

The phase IV clinical study analyzes what interactions people have when they take Diphen and Fentanyl transdermal system. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Fentanyl transdermal system?

Fentanyl transdermal system has active ingredients of fentanyl. It is often used in pain. eHealthMe is studying from 5,728 Fentanyl transdermal system users. Check the latest studies of Fentanyl transdermal system.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 18, 2026

25 people who take Diphen and Fentanyl transdermal system together, and have interactions are studied.

Diphen and Fentanyl transdermal system drug interactions.

What are the common drug interactions of Diphen and Fentanyl Transdermal System, by gender? *:

female:

Pneumonia
Alanine aminotransferase increased
Aspartate aminotransferase increased
Gamma-glutamyltransferase increased
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatic fibrosis (scarring process that represents the liver's response to injury)
Hepatitis c
Drug abuse
Myocarditis (inflammation of heart muscle myocardium)
Drug toxicity

male:

Chest pain
Constipation
Drug ineffective
Eating disorder
Electrocardiogram st-t change
Ileus (a painful obstruction of the ileum or other part of the intestine)
Knee arthroplasty
Nausea (feeling of having an urge to vomit)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Small intestinal obstruction (blockage in small intestine)

What are the common drug interactions of Diphen and Fentanyl Transdermal System, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Fluid overload (too much fluid in the blood)
Haematemesis (vomiting of blood)
Abdominal mass (localized enlargement or swelling in the human abdomen)
Blood creatine increased
Blood magnesium decreased
Blood potassium increased
Blood pressure increased
Blood urine present
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Cardiac failure

20-29:

n/a

30-39:

n/a

40-49:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Gamma-glutamyltransferase increased
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatic fibrosis (scarring process that represents the liver's response to injury)
Hepatitis c
Chest pain
Constipation
Drug ineffective
Eating disorder

50-59:

Drug abuse
Myocarditis (inflammation of heart muscle myocardium)
Pneumonia
Dizziness
Drug toxicity
Erythema (redness of the skin)

60+:

Pneumonia
Constipation
Escherichia infection (bacterial infection by escherichia coli)
Fall
General physical health deterioration (weak health status)
Haemodynamic instability (disturbances in the blood movement in our body)
Hypokinesia (decreased bodily movement)
Hypotension (abnormally low blood pressure)
Inflammation
Klebsiella infection

What are the existing conditions these people have? *

Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 7 people, 28.00%
Sinusitis (inflammation of sinus): 5 people, 20.00%
Muscle Aches (muscle pain): 5 people, 20.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 16.00%
Migraine (headache): 4 people, 16.00%
High Blood Pressure: 4 people, 16.00%
Urine Abnormality: 3 people, 12.00%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 3 people, 12.00%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 3 people, 12.00%
Inflammation: 3 people, 12.00%

* Approximation only. Some reports may have incomplete information.

Do you take Diphen and Fentanyl transdermal system?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously