Diphen and Januvia drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Januvia (sitagliptin phosphate). Common drug interactions include vomiting among females and infusion related reaction among males.
The phase IV clinical study analyzes what interactions people have when they take Diphen and Januvia. It is created by eHealthMe based on reports of 932 people who take the same drugs from the FDA, and is updated regularly.
What is Diphen?
Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.
What is Januvia?
Januvia has active ingredients of sitagliptin phosphate. It is often used in diabetes. eHealthMe is studying from 72,817 Januvia users. Check the latest studies of Januvia.
932 people who take Diphen and Januvia together, and have interactions are studied.

What are the common drug interactions of Diphen and Januvia, by gender? *
What are the common drug interactions of Diphen and Januvia, by age (0-1 to 60+)? *
What are the existing conditions these people have? *
* Approximation only. Some reports may have incomplete information.
Do you take Diphen and Januvia?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Diphen and Januvia:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Diphen:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Januvia:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Diphen and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Januvia and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Liao KF, Lin CL, Lai SW, Chen WC, "Sitagliptin use and risk of acute pancreatitis in type 2 diabetes mellitus: a population-based case-control study in Taiwan", European journal of internal medicine, 2016 Jan .
- Belice T, Yuce S, Kizilkaya B, Kurt A, Cure E, "Noncardiac pulmonary edema induced by sitagliptin treatment", Journal of family medicine and primary care, 2014 Jan .
- Misgar, R. A., Bhat, J. A., Wani, A. I., & Bashir, M. I., "Sitagliptin induced splenic infarcts", Clinical Diabetology, 2014 Jan .
- Stricklin SM, Stoecker WV, Rader RK, Hood AF, Litt JZ, Schuman TP, "Persistent edematous-plaque photosensitivity observed with sitagliptin phosphate (Januvia?)", Dermatology online journal, 2012 Feb .
- Liao KF, Lin CL, Lai SW, Chen WC, "Sitagliptin use and risk of acute pancreatitis in type 2 diabetes mellitus: a population-based case-control study in Taiwan", European journal of internal medicine, 2016 Jan .
- Belice T, Yuce S, Kizilkaya B, Kurt A, Cure E, "Noncardiac pulmonary edema induced by sitagliptin treatment", Journal of family medicine and primary care, 2014 Jan .
- Misgar, R. A., Bhat, J. A., Wani, A. I., & Bashir, M. I., "Sitagliptin induced splenic infarcts", Clinical Diabetology, 2014 Jan .
- Stricklin SM, Stoecker WV, Rader RK, Hood AF, Litt JZ, Schuman TP, "Persistent edematous-plaque photosensitivity observed with sitagliptin phosphate (Januvia?)", Dermatology online journal, 2012 Feb .
How the study uses the data?
The study uses data from the FDA. It is based on diphenhydramine hydrochloride and sitagliptin phosphate (the active ingredients of Diphen and Januvia, respectively), and Diphen and Januvia (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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