Diphen and Letairis drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Letairis (ambrisentan). Common drug interactions include musculoskeletal pain among females and dizziness among males.

The phase IV clinical study analyzes what interactions people have when they take Diphen and Letairis. It is created by eHealthMe based on reports of 78 people who take the same drugs from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Letairis?

Letairis has active ingredients of ambrisentan. It is often used in pulmonary hypertension. eHealthMe is studying from 94,041 Letairis users. Check the latest studies of Letairis.

On Jul, 13, 2026

78 people who take Diphen and Letairis together, and have interactions are studied.

What are the common drug interactions of Diphen and Letairis, by gender? *:

female:

Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Alopecia (absence of hair from areas of the body)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Pain
Vomiting
Dizziness
Headache (pain in head)
Pyrexia (fever)

male:

Dizziness
Oedema (fluid collection in tissue)
Influenza
Infusion site extravasation (flow of (blood or lymph) from infusion site)
Pneumonia
Salmonellosis (an infection with salmonella bacteria)
Sinusitis (inflammation of sinus)
Surgery
Weight decreased
Oedema peripheral (superficial swelling)

What are the common drug interactions of Diphen and Letairis, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Abdominal pain upper
Accident
Diarrhoea
Ear infection
Nausea (feeling of having an urge to vomit)
Pain in jaw
Vomiting

10-19:

n/a

20-29:

n/a

30-39:

Oedema peripheral (superficial swelling)
Dizziness
Oedema (fluid collection in tissue)
Device related infection
Alanine aminotransferase increased
Application site hypersensitivity
Aspartate aminotransferase increased
Blood creatine phosphokinase increased
Cardiomyopathy (weakening of the heart muscle)
Catheter site erythema (redness of skin at catheter site)

40-49:

Dyspnoea (difficult or laboured respiration)
Hypotension (abnormally low blood pressure)
Nausea (feeling of having an urge to vomit)
Vomiting
Dizziness
Pleural effusion (water on the lungs)
Pain
Acute respiratory failure
Asthenia (weakness)
Palpitations (feelings or sensations that your heart is pounding or racing)

50-59:

Cancer pain
Carotid artery stenosis (narrowing of carotid artery)
Device dislocation
Drug intolerance (drug sensitivity)
Dyspepsia (indigestion)
Dyspnoea exertional (breathlessness or shortness of breath)
Ear infection
Emotional disorder
Escherichia infection (bacterial infection by escherichia coli)
Essential hypertension (primary hypertension)

60+:

Dyspnoea (difficult or laboured respiration)
Pneumonia
Abdominal distension
Adverse drug reaction
Asthenia (weakness)
Chest discomfort
Death
Dizziness
Dry eye (lack of adequate tears)
Gait disturbance

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 56 people, 71.79%
Immunodeficiency Common Variable: 12 people, 15.38%
Oedema (fluid collection in tissue): 5 people, 6.41%

* Approximation only. Some reports may have incomplete information.

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