Diphen and Linagliptin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Linagliptin (linagliptin). Common drug interactions include eosinophil count increased among females and blood pressure increased among males.

The phase IV clinical study analyzes what interactions people have when they take Diphen and Linagliptin. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Linagliptin?

Linagliptin has active ingredients of linagliptin. eHealthMe is studying from 8,112 Linagliptin users. Check the latest studies of Linagliptin.

On Aug, 05, 2026

81 people who take Diphen and Linagliptin together, and have interactions are studied.

Diphen and Linagliptin drug interactions.

What are the common drug interactions of Diphen and Linagliptin, by gender? *:

female:

Eosinophil count increased
Episcleritis (acute inflammatory disorder of the episclera of eye)
Hyperglycaemia (high blood sugar)
Hyperthyroidism (over activity of the thyroid gland)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Mean cell haemoglobin concentration decreased (less concentration of haemoglobin in a given volume of packed red blood cells)
Mean cell volume decreased (less of the average red blood cell volume)
Monocyte count increased
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
Oedema (fluid collection in tissue)

male:

Blood pressure increased
Weight decreased
Chronic kidney disease
Clostridium test positive
Constipation
Decreased appetite
Discomfort
Gallbladder disorder
Haemoglobin increased
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)

What are the common drug interactions of Diphen and Linagliptin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abdominal pain upper
Abnormal behaviour
Aggression
Agitation (state of anxiety or nervous excitement)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anxiety
Asthenia (weakness)
Back pain
Blood glucose decreased
Blood pressure fluctuation

50-59:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Haematuria (presence of blood in urine)
Radiculopathy (a set of conditions in which one or more nerves is affected and does not work properly)
Spinal compression fracture (fracture due to spinal compression on bone)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Emotional distress
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Pain

60+:

Dyspnoea (difficult or laboured respiration)
Arthralgia (joint pain)
Blood pressure systolic increased
Contusion (a type of hematoma of tissue in which capillaries)
Cushingoid (obesity and weakening of the muscles)
Dehydration (dryness resulting from the removal of water)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Eosinophil count increased
Episcleritis (acute inflammatory disorder of the episclera of eye)
Hyperglycaemia (high blood sugar)

What are the existing conditions these people have? *

High Blood Pressure: 16 people, 19.75%
Diabetes: 12 people, 14.81%
Vasculitis (inflammation of a blood vessel or blood vessels): 11 people, 13.58%
Constipation: 8 people, 9.88%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 8.64%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 7.41%
Pain: 6 people, 7.41%
Gout (uric acid crystals building up in the body): 6 people, 7.41%
Back Pain: 6 people, 7.41%
Ankylosing Spondylitis (type of arthritis affecting the spine): 6 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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