Diphen and Naratriptan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Naratriptan (naratriptan). Common drug interactions include dyspnoea among females and urticaria among males.

The phase IV clinical study analyzes what interactions people have when they take Diphen and Naratriptan. It is created by eHealthMe based on reports of 95 people who take the same drugs from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,428 Diphen users. Check the latest studies of Diphen.

What is Naratriptan?

Naratriptan has active ingredients of naratriptan. It is often used in migraine. eHealthMe is studying from 1,481 Naratriptan users. Check the latest studies of Naratriptan.



On Sep, 22, 2025

95 people who take Diphen and Naratriptan together, and have interactions are studied.

Diphen and Naratriptan drug interactions.

What are the common drug interactions of Diphen and Naratriptan, by gender? *:

female:

  1. Dyspnoea (difficult or laboured respiration)
  2. Headache (pain in head)
  3. Seasonal allergy (allergic condition due to certain season)
  4. Contusion (a type of hematoma of tissue in which capillaries)
  5. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  6. Urinary tract infection
  7. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  8. Nasopharyngitis (inflammation of the nasopharynx)
  9. Cerebral haemorrhage (bleeding within the brain)
  10. Ear infection

male:

  1. Urticaria (rash of round, red welts on the skin that itch intensely)
  2. Hospitalisation
  3. Swelling face
  4. Dyspnoea (difficult or laboured respiration)
  5. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  6. Rash
  7. Urinary tract infection

What are the common drug interactions of Diphen and Naratriptan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Dyspnoea (difficult or laboured respiration)
  2. Hospitalisation
  3. Swelling face
  4. Urinary tract infection
  5. Urticaria (rash of round, red welts on the skin that itch intensely)

30-39:

  1. Dysgeusia (disorder of the sense of taste)
  2. Headache (pain in head)
  3. Arthralgia (joint pain)
  4. Neck pain
  5. Malaise (a feeling of general discomfort or uneasiness)
  6. Diarrhoea
  7. Drug ineffective
  8. Vision blurred

40-49:

  1. Alopecia (absence of hair from areas of the body)
  2. Hair colour changes
  3. Hair disorder
  4. Neoplasm recurrence (reoccurrence of tumour)
  5. Dystonia (abnormal muscle tone)
  6. Fall
  7. Herpes zoster
  8. Infusion site haemorrhage (bleeding from infusion site)
  9. Opisthotonus (a condition in which the body is held in an abnormal position)
  10. Oral herpes (viral infection of mouth)

50-59:

n/a

60+:

  1. Dyspnoea (difficult or laboured respiration)
  2. Fall
  3. Pneumonia
  4. Scratch
  5. Sinusitis (inflammation of sinus)
  6. Skin atrophy (wasting of skin)
  7. Upper limb fracture
  8. Breast cancer
  9. Road traffic accident
  10. Asthma

What are the existing conditions these people have? *

  1. Immunodeficiency Common Variable: 34 people, 35.79%
  2. Pain: 7 people, 7.37%
  3. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 7.37%
  4. Skin Candida (fungal infection of skin): 6 people, 6.32%
  5. Asthma: 6 people, 6.32%
  6. Primary Immunodeficiency Syndrome: 5 people, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Diphen and Naratriptan?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Diphen and Naratriptan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Diphen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Naratriptan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Diphen and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Naratriptan and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride and naratriptan (the active ingredients of Diphen and Naratriptan, respectively), and Diphen and Naratriptan (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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