Diphen and Pancreaze drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Pancreaze (pancrelipase (amylase;lipase;protease)). Common drug interactions include bladder disorder among females and eye swelling among males.

The phase IV clinical study analyzes what interactions people have when they take Diphen and Pancreaze. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Pancreaze?

Pancreaze has active ingredients of pancrelipase (amylase;lipase;protease). eHealthMe is studying from 847 Pancreaze users. Check the latest studies of Pancreaze.



On Aug, 06, 2026

25 people who take Diphen and Pancreaze together, and have interactions are studied.

Diphen and Pancreaze drug interactions.

What are the common drug interactions of Diphen and Pancreaze, by gender? *:

female:

  1. Bladder disorder
  2. Blood potassium decreased
  3. Cough
  4. Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
  5. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  6. Irritable bowel syndrome
  7. Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
  8. Neoplasm malignant (cancer tumour)
  9. Oropharyngeal pain
  10. Osteoarthritis (a joint disease caused by cartilage loss in a joint)

male:

  1. Eye swelling
  2. Headache (pain in head)
  3. Lip swelling
  4. Nausea (feeling of having an urge to vomit)
  5. Oropharyngeal swelling

What are the common drug interactions of Diphen and Pancreaze, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Ear pain
  2. Headache (pain in head)
  3. Pneumonia
  4. Sinus congestion (blockage of sinus)

40-49:

  1. Abdominal pain upper
  2. Headache (pain in head)
  3. Pain

50-59:

n/a

60+:

  1. Aphonia (inability to produce voice)
  2. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  3. Irritable bowel syndrome
  4. Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
  5. Neoplasm malignant (cancer tumour)
  6. Oropharyngeal pain
  7. Osteoarthritis (a joint disease caused by cartilage loss in a joint)
  8. Pain in extremity
  9. Pancreatic disorder
  10. Skin cancer

What are the existing conditions these people have? *

  1. Immunodeficiency Common Variable: 12 people, 48.00%
  2. Cystic Fibrosis (disease of the secretary glands): 6 people, 24.00%
  3. Intestinal Obstruction: 2 people, 8.00%
  4. Hiv Infection: 2 people, 8.00%
  5. Combined Immunodeficiency: 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

Do you take Diphen and Pancreaze?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Diphen and Pancreaze:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Diphen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Pancreaze:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Diphen and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Pancreaze and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride and pancrelipase (amylase;lipase;protease) (the active ingredients of Diphen and Pancreaze, respectively), and Diphen and Pancreaze (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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