Diphen and Samsca drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Samsca (tolvaptan). Common drug interactions include anaemia among females and bronchial carcinoma among males.

The phase IV clinical study analyzes what interactions people have when they take Diphen and Samsca. It is created by eHealthMe based on reports of 7 people who take the same drugs from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,429 Diphen users. Check the latest studies of Diphen.

What is Samsca?

Samsca has active ingredients of tolvaptan. eHealthMe is studying from 8,139 Samsca users. Check the latest studies of Samsca.

On Dec, 29, 2025

7 people who take Diphen and Samsca together, and have interactions are studied.

What are the common drug interactions of Diphen and Samsca, by gender? *:

female:

Anaemia (lack of blood)
Abdominal distension
Biliary tract disorder
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Burning sensation
Eye irritation
Ocular hyperaemia (an abnormally large amount of blood in eye)
Rhinalgia (pain in the nose)
Swelling
Activities of daily living impaired

male:

Bronchial carcinoma (lung cancer)
Fatigue (feeling of tiredness)
Neoplasm progression (growth of tumour)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Respiratory tract infection
Somnolence (a state of near-sleep, a strong desire for sleep)
Upper respiratory tract infection

What are the common drug interactions of Diphen and Samsca, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Activities of daily living impaired
Altered state of consciousness (altered state of mind)
Anaemia (lack of blood)
C-reactive protein increased
Clavicle fracture
Constipation
Contusion (a type of hematoma of tissue in which capillaries)
Disuse syndrome (deterioration of body systems as a result of prescribed or unavoidable inactivity)
Dry skin
Fall

30-39:

n/a

40-49:

Anaemia (lack of blood)
Burning sensation
Eye irritation
Ocular hyperaemia (an abnormally large amount of blood in eye)
Rhinalgia (pain in the nose)
Swelling

50-59:

n/a

60+:

Glomerular filtration rate decreased
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Melaena (the passage of black, tarry stools)
Neoplasm progression (growth of tumour)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Respiratory tract infection
Somnolence (a state of near-sleep, a strong desire for sleep)
Upper respiratory tract infection
Pruritus (severe itching of the skin)
Abdominal distension

* Approximation only. Some reports may have incomplete information.

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