Sandimmune and Diphen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sandimmune (cyclosporine) and Diphen (diphenhydramine hydrochloride). Common drug interactions include alanine aminotransferase increased among females and aplastic anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Sandimmune and Diphen. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Sandimmune?

Sandimmune has active ingredients of cyclosporine. eHealthMe is studying from 6,694 Sandimmune users. Check the latest studies of Sandimmune.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

On Apr, 23, 2026

12 people who take Sandimmune and Diphen together, and have interactions are studied.

Sandimmune and Diphen drug interactions.

What are the common drug interactions of Sandimmune and Diphen, by gender? *:

female:

Alanine aminotransferase increased
Arthralgia (joint pain)
Aspartate aminotransferase increased
Blood glucose increased
Blood urea increased
Chills (felling of cold)
Cough
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dizziness
Dysuria (painful or difficult urination)

male:

Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Aspergillosis (an infection caused by a fungus called aspergillus)
Febrile neutropenia (fever with reduced white blood cells)
Immunosuppression
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Drug hypersensitivity
Urticaria (rash of round, red welts on the skin that itch intensely)

What are the common drug interactions of Sandimmune and Diphen, by age (0-1 to 60+)? *:

0-1:

Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Hypertension (high blood pressure)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Inappropriate adh secretion
Overdose
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

2-9:

Cough
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dizziness
Dysuria (painful or difficult urination)
Erythema (redness of the skin)
Escherichia urinary tract infection (urinary tract infection by escherichia coli)
Fatigue (feeling of tiredness)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Headache (pain in head)
Hepatic steatosis (fatty liver disease)

10-19:

Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Aspergillosis (an infection caused by a fungus called aspergillus)
Febrile neutropenia (fever with reduced white blood cells)
Immunosuppression
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Drug hypersensitivity

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Urticaria (rash of round, red welts on the skin that itch intensely)

60+:

Hepatocellular damage (liver damage)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 4 people, 33.33%
Uveitis (inflammation of the uvea): 2 people, 16.67%
Seasonal Allergy (allergic condition due to certain season): 2 people, 16.67%
Nausea (feeling of having an urge to vomit): 2 people, 16.67%
Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 2 people, 16.67%
High Blood Pressure: 2 people, 16.67%
Genital Rash (rash on sex organ): 2 people, 16.67%
Anaemia (lack of blood): 2 people, 16.67%
Allergic Rhinitis: 2 people, 16.67%
Abdominal Pain: 2 people, 16.67%

* Approximation only. Some reports may have incomplete information.

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