Diphen and Sotret drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Sotret (isotretinoin). Common drug interactions include hypercalcaemia among females and influenza among males.

The phase IV clinical study analyzes what interactions people have when they take Diphen and Sotret. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Sotret?

Sotret has active ingredients of isotretinoin. It is often used in acne. eHealthMe is studying from 9,023 Sotret users. Check the latest studies of Sotret.

On Jul, 13, 2026

23 people who take Diphen and Sotret together, and have interactions are studied.

What are the common drug interactions of Diphen and Sotret, by gender? *:

female:

Hypercalcaemia (elevated calcium (ca+) level in the blood)
Cough
Hypokalaemia (low potassium)
Pyrexia (fever)
Rash

male:

Influenza
Sinusitis (inflammation of sinus)
Respiratory tract infection
Abscess limb (limb infection)
Cellulitis of male external genital organ (infection of male genitals soft tissue)
Chronic kidney disease
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Hyperkalaemia (damage to or disease of the kidney)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Mydriasis (a dilation of the pupil)

What are the common drug interactions of Diphen and Sotret, by age (0-1 to 60+)? *:

0-1:

Hypokalaemia (low potassium)

2-9:

Device related infection
Febrile neutropenia (fever with reduced white blood cells)
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Cough
Mydriasis (a dilation of the pupil)
Photophobia (extreme sensitivity to light)
Pupillary reflex impaired
Pyrexia (fever)
Rash

10-19:

n/a

20-29:

Nephrogenic anaemia (anaemia due to kidney disease)
Orchitis (inflammation of the testes)
Scrotal abscess (pus in scrotum)
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection
Abscess limb (limb infection)
Cellulitis of male external genital organ (infection of male genitals soft tissue)
Chronic kidney disease
Hyperkalaemia (damage to or disease of the kidney)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)

30-39:

Headache (pain in head)
Infusion related reaction
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Paranasal sinus discomfort
Respiratory tract infection

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 10 people, 43.48%
Cervix Carcinoma (cancer of cervix): 7 people, 30.43%
Neuroblastoma (a cancer that forms in your nerve tissue): 4 people, 17.39%
Immunodeficiency: 3 people, 13.04%
Hiv Infection: 3 people, 13.04%
Cachexia (loss of weight): 3 people, 13.04%

* Approximation only. Some reports may have incomplete information.

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