Diphen and Symproic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Symproic (naldemedine tosylate). Common drug interactions include urinary tract infection among females and oxygen saturation decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Diphen and Symproic. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Symproic?

Symproic has active ingredients of naldemedine tosylate. eHealthMe is studying from 1,487 Symproic users. Check the latest studies of Symproic.

On Jul, 24, 2026

29 people who take Diphen and Symproic together, and have interactions are studied.

What are the common drug interactions of Diphen and Symproic, by gender? *:

female:

Urinary tract infection
Fatigue (feeling of tiredness)
Infusion related reaction
Pain
Abdominal pain
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Fall
Blood glucose increased
Malaise (a feeling of general discomfort or uneasiness)

male:

Oxygen saturation decreased
Angina pectoris (chest pain due to ischemia of the heart muscle)
Dehydration (dryness resulting from the removal of water)
Depressed level of consciousness
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Epistaxis (bleed from the nose)
Erythema (redness of the skin)
Haemoglobin decreased
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)

What are the common drug interactions of Diphen and Symproic, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Facial paralysis (loss of function of face muscle)

30-39:

Fall
Monoplegia (a paralysis of a single limb)
Urinary tract infection
Abdominal infection
Anaphylactic reaction (serious allergic reaction)
Back disorder
Cardiac failure
Dyspnoea (difficult or laboured respiration)
Gait disturbance
Infusion site extravasation (flow of (blood or lymph) from infusion site)

40-49:

Abdominal pain
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Drug hypersensitivity
Bone tuberculosis
Non-small cell lung cancer (type of epithelial lung cancer)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Seasonal allergy (allergic condition due to certain season)

50-59:

n/a

60+:

Drug ineffective
Oxygen saturation decreased
Chest pain
Constipation
Cystitis (inflammation of the wall of the bladder)
Death
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dehydration (dryness resulting from the removal of water)
Depressed level of consciousness
Diarrhoea

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 13 people, 44.83%
Constipation: 7 people, 24.14%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 4 people, 13.79%
Seasonal Allergy (allergic condition due to certain season): 3 people, 10.34%
Neck Pain: 3 people, 10.34%
Lymphorrhea: 3 people, 10.34%
Itching: 3 people, 10.34%
Dry Eyes (lack of adequate tears): 3 people, 10.34%
Deafness Neurosensory: 3 people, 10.34%
Cataract (clouding of the lens inside the eye): 3 people, 10.34%

* Approximation only. Some reports may have incomplete information.

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