Diphen and Temodar drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Temodar (temozolomide). Common drug interactions include spinal cord disorder among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Diphen and Temodar. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Temodar?

Temodar has active ingredients of temozolomide. It is often used in glioblastoma multiforme. eHealthMe is studying from 6,683 Temodar users. Check the latest studies of Temodar.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

23 people who take Diphen and Temodar together, and have interactions are studied.

What are the common drug interactions of Diphen and Temodar, by gender? *:

female:

Spinal cord disorder (disease of spinal cord)
Tooth disorder (tooth disease)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Urinary retention (the inability to completely or partially empty the bladder)
Weight decreased
Wound
Thrombocytopenia (decrease of platelets in blood)
Dehydration (dryness resulting from the removal of water)
Headache (pain in head)
Neutropenia (an abnormally low number of neutrophils)

male:

Death
Acne (skin problems that cause pimples)
Metastases to lung (cancer spreads to lung)
Metastases to meninges (cancer spreads to meninges)
Visual acuity reduced (reduced clearness of vision)
Nausea (feeling of having an urge to vomit)
Thrombocytopenia (decrease of platelets in blood)
Vomiting
Cerebral hypoperfusion (a condition in which the brain doesn't get enough blood)
Cough

What are the common drug interactions of Diphen and Temodar, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Urinary incontinence (inability to control the flow of urine and involuntary urination)
Urinary retention (the inability to completely or partially empty the bladder)
Vomiting
Diarrhoea
Hypoaesthesia (reduced sense of touch or sensation)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Myelitis (infection or the inflammation of white matter or gray matter of spinal cord which is a part of central nervous system)
Myelopathy (any neurologic deficit related to the spinal cord)
Nausea (feeling of having an urge to vomit)
Pain in extremity

20-29:

n/a

30-39:

n/a

40-49:

Death
Acne (skin problems that cause pimples)
Cerebral hypoperfusion (a condition in which the brain doesn't get enough blood)
Cough
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Dilatation ventricular
Eating disorder
Fatigue (feeling of tiredness)
Headache (pain in head)
Leukopenia (less number of white blood cells in blood)

50-59:

Thrombocytopenia (decrease of platelets in blood)
Dehydration (dryness resulting from the removal of water)
Headache (pain in head)
Neutropenia (an abnormally low number of neutrophils)
Pulmonary embolism (blockage of the main artery of the lung)
Abdominal tenderness
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Leukopenia (less number of white blood cells in blood)
Pyrexia (fever)

60+:

Constipation
Diarrhoea
Hypoaesthesia (reduced sense of touch or sensation)
Impaired healing
Intervertebral disc degeneration (spinal disc degeneration)
Joint swelling
Malaise (a feeling of general discomfort or uneasiness)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Oedema (fluid collection in tissue)
Oral candidiasis (fungal infection of mouth)

What are the existing conditions these people have? *

Hepatic Neoplasm Malignant (liver cancer): 5 people, 21.74%
Glioma (a type of tumour that starts in the brain or spine): 4 people, 17.39%
Brain Neoplasm Malignant (brain cancer tumour): 3 people, 13.04%
Nausea (feeling of having an urge to vomit): 2 people, 8.70%
Lung Neoplasm Malignant (cancer tumour of lung): 2 people, 8.70%
Carcinoid Tumor: 2 people, 8.70%
Carcinoid Syndrome (syndrome includes flushing and diarrhoea, and, less frequently, heart failure and bronchoconstriction): 2 people, 8.70%
Brain Stem Glioma (cancerous glioma tumour in the brainstem): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

Do you take Diphen and Temodar?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously