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Diphen and Tyvaso dpi drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Tyvaso dpi (treprostinil). Common drug interactions include cough among females and atrial fibrillation among males.

The phase IV clinical study analyzes what interactions people have when they take Diphen and Tyvaso dpi. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Tyvaso dpi?

Tyvaso dpi has active ingredients of treprostinil. eHealthMe is studying from 3,551 Tyvaso dpi users. Check the latest studies of Tyvaso dpi.

On Aug, 01, 2026

11 people who take Diphen and Tyvaso dpi together, and have interactions are studied.

Diphen and Tyvaso dpi drug interactions.

What are the common drug interactions of Diphen and Tyvaso Dpi, by gender? *:

female:

  1. Cough
  2. Drug tolerance decreased
  3. Headache (pain in head)
  4. Pain in extremity
  5. Chest pain
  6. Dyspnoea (difficult or laboured respiration)
  7. Muscle spasms (muscle contraction)
  8. Bedridden
  9. Cardiac disorder
  10. Ear pain

male:

  1. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  2. Cardiac disorder
  3. Pneumonia
  4. Diarrhoea
  5. Chest discomfort
  6. Chest pain
  7. Cough
  8. Dyspepsia (indigestion)
  9. Dyspnoea (difficult or laboured respiration)
  10. Fluid retention (an abnormal accumulation of fluid in the blood)

What are the common drug interactions of Diphen and Tyvaso Dpi, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Cough
  2. Diarrhoea
  3. Dizziness
  4. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  5. Headache (pain in head)
  6. Hepatic enzyme increased
  7. Hypersensitivity
  8. Abdominal discomfort
  9. Abdominal distension
  10. Abdominal pain upper

60+:

  1. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  2. Cardiac disorder
  3. Fluid retention (an abnormal accumulation of fluid in the blood)
  4. Pericardial effusion (fluid around the heart)
  5. Dehydration (dryness resulting from the removal of water)
  6. Heart rate increased
  7. Death

What are the existing conditions these people have? *

  1. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 10 people, 90.91%
  2. Metastases To Lung (cancer spreads to lung): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Diphen and Tyvaso dpi?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Diphen and Tyvaso dpi:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Diphen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Tyvaso dpi:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Diphen and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Tyvaso dpi and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride and treprostinil (the active ingredients of Diphen and Tyvaso dpi, respectively), and Diphen and Tyvaso dpi (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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