Valtoco and Diphen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Valtoco (diazepam) and Diphen (diphenhydramine hydrochloride). Common drug interactions include seizure among females and influenza among males.

The phase IV clinical study analyzes what interactions people have when they take Valtoco and Diphen. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Valtoco?

Valtoco has active ingredients of diazepam. eHealthMe is studying from 400 Valtoco users. Check the latest studies of Valtoco.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,428 Diphen users. Check the latest studies of Diphen.

On Aug, 18, 2025

26 people who take Valtoco and Diphen together, and have interactions are studied.

What are the common drug interactions of Valtoco and Diphen, by gender? *:

female:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sinusitis (inflammation of sinus)
Blood sodium decreased
Dehydration (dryness resulting from the removal of water)
Ear infection
Upper respiratory tract infection
Anxiety
Cough
Dyskinesia (abnormality or impairment of voluntary movement)
Influenza like illness

male:

Influenza
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Burning sensation
Dehydration (dryness resulting from the removal of water)
Eating disorder
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Haematochezia (passage of stools containing blood)
Hand-foot-and-mouth disease
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Rash

What are the common drug interactions of Valtoco and Diphen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Influenza
Upper respiratory tract infection
Haematochezia (passage of stools containing blood)
Hand-foot-and-mouth disease
Headache (pain in head)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Nasopharyngitis (inflammation of the nasopharynx)
Pyrexia (fever)
Rash
Vomiting

10-19:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Dyspnoea (difficult or laboured respiration)
Fall
Headache (pain in head)
Muscle twitching
Ocular hyperaemia (an abnormally large amount of blood in eye)
Pyrexia (fever)
Cough
Eye infection
Faecaloma (hard mass of fecal matter)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Lennox-Gastaut Syndrome (epilepsy characterized by frequent seizures and different seizure types): 4 people, 15.38%
Immunodeficiency Common Variable: 3 people, 11.54%
Immunodeficiency: 3 people, 11.54%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 3 people, 11.54%
Mitochondrial Myopathy (the muscle fibres do not function due to damage of mitochondria): 2 people, 7.69%
Failure To Thrive (inadequate weight gain and physical growth in children): 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Valtoco and Diphen?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously