Diphen and Xhance drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphen (diphenhydramine hydrochloride) and Xhance (fluticasone propionate). Common drug interactions include sinusitis among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Diphen and Xhance. It is created by eHealthMe based on reports of 86 people who take the same drugs from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Xhance?

Xhance has active ingredients of fluticasone propionate. eHealthMe is studying from 2,012 Xhance users. Check the latest studies of Xhance.

On Jul, 27, 2026

86 people who take Diphen and Xhance together, and have interactions are studied.

What are the common drug interactions of Diphen and Xhance, by gender? *:

female:

Sinusitis (inflammation of sinus)
Pneumonia
Ear infection
Seasonal allergy (allergic condition due to certain season)
Cough
Urinary tract infection
Nasopharyngitis (inflammation of the nasopharynx)
Cystitis (inflammation of the wall of the bladder)
Headache (pain in head)
Omphalitis (medical term for infection of the umbilical cord)

male:

Fatigue (feeling of tiredness)
Sinusitis (inflammation of sinus)
Wheezing (a high-pitched whistling sound made while you breath)
Headache (pain in head)
Infusion related reaction
Infusion site pain
Arthralgia (joint pain)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Mobility decreased (ability to move is reduced)

What are the common drug interactions of Diphen and Xhance, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Pneumonia
Cough
Drug eruption (adverse drug reaction of the skin)
Headache (pain in head)
Ear infection
Infusion related reaction
Infusion site erythema (reddening of the skin at infusion site)
Infusion site pruritus (severe itching at infusion site)
Injection site pain
Nausea (feeling of having an urge to vomit)

40-49:

Asthma
Cystitis (inflammation of the wall of the bladder)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Infusion site erythema (reddening of the skin at infusion site)
Injection site erythema (redness at injection site)
Oral fungal infection
Sinus disorder (disease of sinus)
Sinusitis (inflammation of sinus)
Sinusitis fungal (fungal infection of sinus)
Urinary tract infection

50-59:

Sinusitis (inflammation of sinus)
Omphalitis (medical term for infection of the umbilical cord)
Nasopharyngitis (inflammation of the nasopharynx)
Diarrhoea
Asthma
Cystitis (inflammation of the wall of the bladder)
Sinus disorder (disease of sinus)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Oral fungal infection
Sinusitis fungal (fungal infection of sinus)

60+:

Urinary tract infection
Cystitis (inflammation of the wall of the bladder)
Seasonal allergy (allergic condition due to certain season)
Sinusitis (inflammation of sinus)
Tooth abscess (pus formation in tooth)
Tooth fracture
Upper respiratory tract infection
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cough
Hordeolum (small collection of pus (abscess) on the eyelid)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 52 people, 60.47%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 14 people, 16.28%
Asthma: 12 people, 13.95%
Mitral Valve Stenosis (narrowing of mitral valve): 9 people, 10.47%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 9 people, 10.47%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 9 people, 10.47%
Immunodeficiency: 8 people, 9.30%
Nasal Polyps (masses that develop in the lining of the nose): 7 people, 8.14%
Urinary Tract Infection: 5 people, 5.81%
Sinusitis Fungal (fungal infection of sinus): 5 people, 5.81%

* Approximation only. Some reports may have incomplete information.

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