Diphenhydramine hydrochloride and Aciphex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphenhydramine hydrochloride (diphenhydramine hydrochloride) and Aciphex (rabeprazole sodium). Common drug interactions include ischaemia among females and calculus urethral among males.

The phase IV clinical study analyzes what interactions people have when they take Diphenhydramine hydrochloride and Aciphex. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Diphenhydramine hydrochloride?

Diphenhydramine hydrochloride has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 26,097 Diphenhydramine hydrochloride users. Check the latest studies of Diphenhydramine hydrochloride.

What is Aciphex?

Aciphex has active ingredients of rabeprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 25,301 Aciphex users. Check the latest studies of Aciphex.

On Jul, 09, 2026

28 people who take Diphenhydramine hydrochloride and Aciphex together, and have interactions are studied.

Diphenhydramine hydrochloride and Aciphex drug interactions.

What are the common drug interactions of Diphenhydramine Hydrochloride and Aciphex, by gender? *:

female:

Ischaemia (insufficient supply of blood to an organ, usually due to a blocked artery)
Metastases to bone (cancer spreads to bone)
Metastatic neoplasm (spreadable cancer tumour)
Neuropathy peripheral (surface nerve damage)
Obstruction
Oesophageal ulcer (ulcer of oesophagus)
Pain
Pharyngeal ulceration
Productive cough
Pulmonary embolism (blockage of the main artery of the lung)

male:

Calculus urethral (stone in urethra)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Anxiety
Bone marrow toxicity (decrease in cells responsible for providing immunity, carrying oxygen, and those responsible for normal blood clotting)
Decreased appetite
Dyspnoea (difficult or laboured respiration)
Fluid retention (an abnormal accumulation of fluid in the blood)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haemorrhage (bleeding)
Lung disorder (lung disease)

What are the common drug interactions of Diphenhydramine Hydrochloride and Aciphex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Chest pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Haemarthrosis (haemarthrosis is where blood is able to enter the joint capsule)
Pulmonary embolism (blockage of the main artery of the lung)
Venous thrombosis limb (blood clot that forms in a vein in the limb)

20-29:

n/a

30-39:

n/a

40-49:

Dyspnoea (difficult or laboured respiration)
Chest discomfort
Fatigue (feeling of tiredness)
Hypersensitivity
Lip swelling
Malaise (a feeling of general discomfort or uneasiness)
Pyrexia (fever)
Swelling face
Arthralgia (joint pain)
Blood pressure increased

50-59:

Pain
Weight increased
Calculus urethral (stone in urethra)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Obstruction gastric (obstruction in stomach)
Pancreatitis (inflammation of pancreas)
Pancreatitis acute (sudden inflammation of pancreas)
Type 2 diabetes mellitus
Urethral stenosis (narrowing of the urethra, may cause decreased urine output)
Asthenia (weakness)

60+:

Pruritus (severe itching of the skin)
Urticaria (rash of round, red welts on the skin that itch intensely)
Seasonal allergy (allergic condition due to certain season)
Weight fluctuation
Adverse drug reaction
Anxiety
Bone marrow toxicity (decrease in cells responsible for providing immunity, carrying oxygen, and those responsible for normal blood clotting)
Decreased appetite
Fluid retention (an abnormal accumulation of fluid in the blood)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 13 people, 46.43%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 14.29%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 14.29%
Primary Immunodeficiency Syndrome: 3 people, 10.71%
Nasal Discomfort: 3 people, 10.71%
Itching: 3 people, 10.71%
Hypersensitivity: 3 people, 10.71%
Fungal Infection: 3 people, 10.71%
Bronchial Hyperreactivity: 3 people, 10.71%
Stress And Anxiety: 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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