Diphenhydramine hydrochloride and Requip drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphenhydramine hydrochloride (diphenhydramine hydrochloride) and Requip (ropinirole hydrochloride). Common drug interactions include skin ulcer among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Diphenhydramine hydrochloride and Requip. It is created by eHealthMe based on reports of 78 people who take the same drugs from the FDA, and is updated regularly.

What is Diphenhydramine hydrochloride?

Diphenhydramine hydrochloride has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 26,097 Diphenhydramine hydrochloride users. Check the latest studies of Diphenhydramine hydrochloride.

What is Requip?

Requip has active ingredients of ropinirole hydrochloride. It is often used in restless leg syndrome. eHealthMe is studying from 22,950 Requip users. Check the latest studies of Requip.

On Jul, 11, 2026

78 people who take Diphenhydramine hydrochloride and Requip together, and have interactions are studied.

Diphenhydramine hydrochloride and Requip drug interactions.

What are the common drug interactions of Diphenhydramine Hydrochloride and Requip, by gender? *:

female:

Skin ulcer
Small intestinal obstruction (blockage in small intestine)
Surgery
Tooth abscess (pus formation in tooth)
Weight increased
White blood cell count increased
Abdominal hernia
Abdominal pain upper
Abnormal dreams
Anaemia (lack of blood)

male:

Anxiety
Depression
Hepatomegaly (abnormal enlargement of the liver)
Blood cholesterol increased
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Sternal fracture
Blood pressure increased
Cardiac disorder
Contusion (a type of hematoma of tissue in which capillaries)
Cough

What are the common drug interactions of Diphenhydramine Hydrochloride and Requip, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Fatigue (feeling of tiredness)
Hypertonic bladder (bladder-storage function that causes a sudden urge to urinate)
Intervertebral disc protrusion (spinal disc protrusion)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Synovial cyst (cyst of joint filled with synovial fluid)

30-39:

Food craving
Sleep-related eating disorder (abnormal eating patterns during the night)
Somnambulism (sleep walking)
Borderline personality disorder
Drug ineffective
Meniere's disease (a disorder of the inner ear that can affect hearing and balance to a varying degree)
Therapeutic response unexpected

40-49:

Blood cholesterol increased
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Abdominal pain
Burning sensation
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Colitis (inflammation of colon)
Cough
Drug ineffective
Fatigue (feeling of tiredness)
Muscle stiffness

50-59:

Cystitis (inflammation of the wall of the bladder)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dyspnoea (difficult or laboured respiration)
Hereditary angioedema (recurrent episodes of severe swelling)
Influenza
Infusion site discomfort
Infusion site pain
Infusion site pruritus (severe itching at infusion site)
Kidney infection
Pharyngitis (inflammation of the pharynx, causing a sore throat)

60+:

Abdominal pain
Chest pain
Weight decreased
Abdominal hernia
Abdominal pain upper
Anaemia (lack of blood)
Asthma
Cellulitis (infection under the skin)
Cough
Diarrhoea

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 42 people, 53.85%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 38 people, 48.72%
Immunodeficiency Common Variable: 15 people, 19.23%
Drowsiness: 8 people, 10.26%
Rashes (redness): 4 people, 5.13%
Primary Immunodeficiency Syndrome: 4 people, 5.13%
Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 4 people, 5.13%
Pain: 4 people, 5.13%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 4 people, 5.13%

* Approximation only. Some reports may have incomplete information.

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