Diphenhydramine hydrochloride and Tecfidera drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diphenhydramine hydrochloride (diphenhydramine hydrochloride) and Tecfidera (dimethyl fumarate). Common drug interactions include drug ineffective among females and arrhythmia among males.

The phase IV clinical study analyzes what interactions people have when they take Diphenhydramine hydrochloride and Tecfidera. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Diphenhydramine hydrochloride?

Diphenhydramine hydrochloride has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 26,097 Diphenhydramine hydrochloride users. Check the latest studies of Diphenhydramine hydrochloride.

What is Tecfidera?

Tecfidera has active ingredients of dimethyl fumarate. It is often used in multiple sclerosis. eHealthMe is studying from 129,627 Tecfidera users. Check the latest studies of Tecfidera.

On Jul, 15, 2026

17 people who take Diphenhydramine hydrochloride and Tecfidera together, and have interactions are studied.

Diphenhydramine hydrochloride and Tecfidera drug interactions.

What are the common drug interactions of Diphenhydramine Hydrochloride and Tecfidera, by gender? *:

female:

Drug ineffective
Back pain
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nasopharyngitis (inflammation of the nasopharynx)
Headache (pain in head)
Nephrolithiasis (calculi in the kidneys)
Pain
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Abasia (inability to walk)

male:

Arrhythmia (irregular heartbeat)
Cough
Suicide attempt
Mania (a state of abnormally elevated or irritable mood)
Pain
Post-traumatic stress disorder
Psychotic disorder
Somnambulism (sleep walking)
Stress
Suicidal ideation

What are the common drug interactions of Diphenhydramine Hydrochloride and Tecfidera, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Arrhythmia (irregular heartbeat)
Cough
Mania (a state of abnormally elevated or irritable mood)
Pain
Post-traumatic stress disorder
Psychotic disorder
Somnambulism (sleep walking)
Stress
Suicidal ideation

40-49:

Heart rate increased
Anxiety
Aphasia (damage to the parts of the brain that control language)
Asthenia (weakness)
Blood pressure increased
Cataplexy (loss of muscle tone accompanied by full conscious awareness)
Disability
Headache (pain in head)
Hypersomnia (excessive daytime sleepiness (eds))
Hypnagogic hallucination

50-59:

Abasia (inability to walk)
Back pain
Drug ineffective
Dysstasia (difficulty in standing)
Gait disturbance
General physical health deterioration (weak health status)
Mobility decreased (ability to move is reduced)
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 11 people, 64.71%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 52.94%
Constipation: 2 people, 11.76%
Urinary Tract Infection: 1 person, 5.88%
Gait Disturbance: 1 person, 5.88%
Common Peroneal Nerve Dysfunction (dysfunction of nerve controlling movement and sensation to the lower leg, foot and toes): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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