Diprivan and Singulair drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diprivan (propofol) and Singulair (montelukast sodium). Common drug interactions include nausea among females and acute respiratory distress syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Diprivan and Singulair. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Diprivan?

Diprivan has active ingredients of propofol. eHealthMe is studying from 6,496 Diprivan users. Check the latest studies of Diprivan.

What is Singulair?

Singulair has active ingredients of montelukast sodium. It is often used in asthma. eHealthMe is studying from 129,752 Singulair users. Check the latest studies of Singulair.



On Jul, 08, 2026

51 people who take Diprivan and Singulair together, and have interactions are studied.

Diprivan and Singulair drug interactions.

What are the common drug interactions of Diprivan and Singulair, by gender? *:

female:

  1. Nausea (feeling of having an urge to vomit)
  2. Osteonecrosis of jaw (death of bone of jaw)
  3. Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
  4. Anxiety
  5. Foot deformity (functional disability of foot)
  6. Otitis externa (external ear infection)
  7. Cor pulmonale chronic (long lasting enlargement of the right ventricle of the heart)
  8. Gastroduodenitis (an inflammation of the mucous membrane of the stomach and duodenum)
  9. Uterine enlargement
  10. Weight decreased

male:

  1. Acute respiratory distress syndrome
  2. Acute respiratory failure
  3. Angioedema (rapid swelling of the dermis)
  4. Aspartate aminotransferase increased
  5. Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
  6. Circulatory collapse
  7. Dysphagia (a condition in which swallowing is difficult or painful)
  8. Generalised oedema (swelling all over the body)
  9. Oxygen saturation decreased
  10. Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)

What are the common drug interactions of Diprivan and Singulair, by age (0-1 to 60+)? *:

0-1:

  1. Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
  2. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  3. Pulmonary hypertension (increase in blood pressure in the lung artery)

2-9:

n/a

10-19:

  1. Angioedema (rapid swelling of the dermis)
  2. Cholecystitis chronic (long lasting infection of gallbladder)
  3. Oxygen saturation decreased
  4. Urticaria (rash of round, red welts on the skin that itch intensely)

20-29:

n/a

30-39:

  1. Abdominal pain upper
  2. Anaphylactic reaction (serious allergic reaction)
  3. Angioedema (rapid swelling of the dermis)
  4. Anxiety
  5. Brain injury
  6. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  7. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  8. Drooling (drop saliva uncontrollably from the mouth)
  9. Dysphagia (a condition in which swallowing is difficult or painful)
  10. Dysphonia (speech disorder attributable to a disorder of phonation)

40-49:

  1. Dysphagia (a condition in which swallowing is difficult or painful)
  2. Dyspnoea (difficult or laboured respiration)
  3. Muscle tightness

50-59:

  1. Osteomyelitis (infection of bone)
  2. Osteopenia (a condition where bone mineral density is lower than normal)
  3. Osteoporosis (bones weak and more likely to break)
  4. Pain
  5. Pain in jaw
  6. Pelvic fracture
  7. Periodontal disease (disease that attacks the gum and bone and around the teeth)
  8. Periodontitis (inflammation of the tissue around the teeth)
  9. Pleural effusion (water on the lungs)
  10. Poor dental condition

60+:

  1. Dyspnoea (difficult or laboured respiration)
  2. Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
  3. Acute respiratory failure
  4. Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
  5. Cytokine storm (over-protective immune response that can actually be fatal)
  6. Death
  7. Glomerular filtration rate decreased
  8. Hyperkalaemia (damage to or disease of the kidney)
  9. Leukocytosis (increased white blood cells)
  10. Thrombocytopenia (decrease of platelets in blood)

What are the existing conditions these people have? *

  1. Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 27 people, 52.94%
  2. Osteoporosis (bones weak and more likely to break): 27 people, 52.94%
  3. Thrombocytopenia (decrease of platelets in blood): 11 people, 21.57%
  4. Pain: 7 people, 13.73%
  5. High Blood Pressure: 5 people, 9.80%
  6. Anaesthesia: 5 people, 9.80%
  7. Anaemia (lack of blood): 5 people, 9.80%
  8. Breast Infection: 4 people, 7.84%
  9. Lipids Increased (excess lipid in body): 3 people, 5.88%
  10. Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 3 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Diprivan and Singulair:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Diprivan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Singulair:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Diprivan and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Singulair and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on propofol and montelukast sodium (the active ingredients of Diprivan and Singulair, respectively), and Diprivan and Singulair (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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