Ditropan and Nucynta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ditropan (oxybutynin chloride) and Nucynta (tapentadol hydrochloride). Common drug interactions include fatigue among females and neuropathy peripheral among males.

The phase IV clinical study analyzes what interactions people have when they take Ditropan and Nucynta. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Ditropan?

Ditropan has active ingredients of oxybutynin chloride. It is often used in urge incontinence. eHealthMe is studying from 11,799 Ditropan users. Check the latest studies of Ditropan.

What is Nucynta?

Nucynta has active ingredients of tapentadol hydrochloride. It is often used in pain. eHealthMe is studying from 31,818 Nucynta users. Check the latest studies of Nucynta.

On Jul, 12, 2026

24 people who take Ditropan and Nucynta together, and have interactions are studied.

What are the common drug interactions of Ditropan and Nucynta, by gender? *:

female:

Fatigue (feeling of tiredness)
Death
Nausea (feeling of having an urge to vomit)
Blood glucose fluctuation
Depression
Dyspnoea (difficult or laboured respiration)
Hypoaesthesia (reduced sense of touch or sensation)
Migraine (headache)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nocturia (the need to get up in the night to urinate)

male:

Neuropathy peripheral (surface nerve damage)
Arthropathy
Cataract (clouding of the lens inside the eye)
Dysphagia (a condition in which swallowing is difficult or painful)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Rash
Schizophrenia (a mental disorder characterized by a breakdown of thought processes)
Schizophrenia, paranoid type (delusions and auditory hallucinations but relatively normal intellectual functioning and expression of affect)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

What are the common drug interactions of Ditropan and Nucynta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Death
Hypoaesthesia (reduced sense of touch or sensation)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cataract (clouding of the lens inside the eye)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Neuropathy peripheral (surface nerve damage)
Pulmonary hypertension (increase in blood pressure in the lung artery)

40-49:

Schizophrenia (a mental disorder characterized by a breakdown of thought processes)
Schizophrenia, paranoid type (delusions and auditory hallucinations but relatively normal intellectual functioning and expression of affect)

50-59:

Fatigue (feeling of tiredness)
Blood glucose fluctuation
Depression
Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Nocturia (the need to get up in the night to urinate)
Obesity (having too much body fat)
Osteoporosis (bones weak and more likely to break)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Tardive dyskinesia (a disorder that involves involuntary movements)

60+:

Headache (pain in head)
Arthropathy
Cellulitis (infection under the skin)
Dysphagia (a condition in which swallowing is difficult or painful)
Nausea (feeling of having an urge to vomit)
Rash
Dyspnoea (difficult or laboured respiration)
Hypoaesthesia (reduced sense of touch or sensation)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Neck pain

What are the existing conditions these people have? *

Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 6 people, 25.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 25.00%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 4 people, 16.67%
Muscle Spasms (muscle contraction): 4 people, 16.67%
Thrombosis (formation of a blood clot inside a blood vessel): 4 people, 16.67%
Insomnia (sleeplessness): 3 people, 12.50%
Urine Abnormality: 2 people, 8.33%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 2 people, 8.33%
Constipation: 2 people, 8.33%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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