Divalproex sodium and Colace drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Divalproex sodium (divalproex sodium) and Colace (docusate ). Common drug interactions include dermatitis contact among females and agitation among males.

The phase IV clinical study analyzes what interactions people have when they take Divalproex sodium and Colace. It is created by eHealthMe based on reports of 93 people who take the same drugs from the FDA, and is updated regularly.

What is Divalproex sodium?

Divalproex sodium has active ingredients of divalproex sodium. It is often used in epilepsy. eHealthMe is studying from 9,483 Divalproex sodium users. Check the latest studies of Divalproex sodium.

What is Colace?

Colace has active ingredients of docusate . It is often used in constipation. eHealthMe is studying from 41,841 Colace users. Check the latest studies of Colace.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

93 people who take Divalproex sodium and Colace together, and have interactions are studied.

Divalproex sodium and Colace drug interactions.

What are the common drug interactions of Divalproex Sodium and Colace, by gender? *:

female:

Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Pneumonia
Arthralgia (joint pain)
Back pain
Diarrhoea
Nausea (feeling of having an urge to vomit)
Spinal disorder (disease of spine a back bone)
Urinary tract infection
Chills (felling of cold)

male:

Agitation (state of anxiety or nervous excitement)
Blood creatinine increased
Malaise (a feeling of general discomfort or uneasiness)
Mania (a state of abnormally elevated or irritable mood)
Pco2 decreased
Poor quality sleep
Speech disorder
Urinary tract infection
White blood cell count decreased
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

What are the common drug interactions of Divalproex Sodium and Colace, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Alanine aminotransferase increased
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Aspartate aminotransferase increased
Bile duct stone
Cholecystitis chronic (long lasting infection of gallbladder)
Culture urine positive
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Electrocardiogram qt prolonged
Emotional distress

30-39:

Abdominal discomfort
Abdominal pain
Agitation (state of anxiety or nervous excitement)
Anxiety
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chills (felling of cold)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Cough
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

40-49:

Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Pulmonary embolism (blockage of the main artery of the lung)
Weakness
Respiratory disorder (respiratory disease)
Blood creatinine increased
Blood urea increased
Chills (felling of cold)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Lethargy (tiredness)

50-59:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Septic shock (shock due to blood infection)
Spinal fracture (fracture in one of vertebrae)
Subdural haematoma (blood collects between the skull and the surface of the brain)
Vision blurred
Weight decreased
Weight increased
Abdominal abscess (collection of pus in abdomen)
Adverse drug reaction
Anger

60+:

Fall
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cough
Fatigue (feeling of tiredness)
Haematocrit decreased
Haemoglobin decreased
Pneumonia
Red blood cell count decreased
Spinal disorder (disease of spine a back bone)
Syncope (loss of consciousness with an inability to maintain postural tone)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 21 people, 22.58%
Pain: 12 people, 12.90%
Bipolar Disorder (mood disorder): 12 people, 12.90%
Hypergammaglobulinaemia (elevated levels of gamma globulin): 9 people, 9.68%
High Blood Pressure: 8 people, 8.60%
Sleep Disorder: 5 people, 5.38%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 5 people, 5.38%
Parkinson's Disease: 5 people, 5.38%
Multiple Myeloma (cancer of the plasma cells): 5 people, 5.38%

* Approximation only. Some reports may have incomplete information.

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