Divalproex sodium and Sumatriptan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Divalproex sodium (divalproex sodium) and Sumatriptan (sumatriptan succinate). Common drug interactions include nephrolithiasis among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Divalproex sodium and Sumatriptan. It is created by eHealthMe based on reports of 65 people who take the same drugs from the FDA, and is updated regularly.

What is Divalproex sodium?

Divalproex sodium has active ingredients of divalproex sodium. It is often used in epilepsy. eHealthMe is studying from 9,483 Divalproex sodium users. Check the latest studies of Divalproex sodium.

What is Sumatriptan?

Sumatriptan has active ingredients of sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 18,159 Sumatriptan users. Check the latest studies of Sumatriptan.

On Jul, 15, 2026

65 people who take Divalproex sodium and Sumatriptan together, and have interactions are studied.

Divalproex sodium and Sumatriptan drug interactions.

What are the common drug interactions of Divalproex Sodium and Sumatriptan, by gender? *:

female:

Nephrolithiasis (calculi in the kidneys)
Neuropathy peripheral (surface nerve damage)
Overdose
Pain in extremity
Rectal bleeding (bleeding from rectum)
Renal injury (kidney injury)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Skin nodule (slightly elevated lesions on or in the skin)
Somnolence (a state of near-sleep, a strong desire for sleep)
Sweating increased (excess sweating)

male:

Drug ineffective
Renal failure (kidney dysfunction)
Osteoporosis (bones weak and more likely to break)
Pain
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Suicidal ideation
Inflammation
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Adverse event
Agitation (state of anxiety or nervous excitement)

What are the common drug interactions of Divalproex Sodium and Sumatriptan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anxiety
Chronic kidney disease
Renal failure (kidney dysfunction)
Fibromyalgia (a long-term condition which causes pain all over the body)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Mania (a state of abnormally elevated or irritable mood)
Neuropathy peripheral (surface nerve damage)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Abdominal pain

40-49:

Lymphadenopathy (disease or enlargement of lymph nodes)
Pain
Rectal bleeding (bleeding from rectum)
Skin nodule (slightly elevated lesions on or in the skin)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Suicide attempt
Adverse event
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)

50-59:

Drug ineffective
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Renal failure (kidney dysfunction)
Suicidal ideation
Abnormal behaviour
Acute respiratory failure
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthralgia (joint pain)
Back disorder

60+:

Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Nervousness
Oedema (fluid collection in tissue)
Panic attack
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Schizophrenia (a mental disorder characterized by a breakdown of thought processes)
Tremor (trembling or shaking movements in one or more parts of your body)
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Abdominal pain upper

What are the existing conditions these people have? *

Pain: 6 people, 9.23%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 9.23%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 9.23%
Stress And Anxiety: 5 people, 7.69%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 7.69%
Hiv Infection: 5 people, 7.69%
Sleep Disorder: 4 people, 6.15%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 6.15%

* Approximation only. Some reports may have incomplete information.

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