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Divigel and Zopiclone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Divigel (estradiol) and Zopiclone (eszopiclone). Common drug interactions include drug level increased among females.

The phase IV clinical study analyzes what interactions people have when they take Divigel and Zopiclone. It is created by eHealthMe based on reports of 99 people who take the same drugs from the FDA, and is updated regularly.

What is Divigel?

Divigel has active ingredients of estradiol. It is often used in menopause. eHealthMe is studying from 894 Divigel users. Check the latest studies of Divigel.

What is Zopiclone?

Zopiclone has active ingredients of eszopiclone. It is often used in insomnia. eHealthMe is studying from 54,331 Zopiclone users. Check the latest studies of Zopiclone.

On Aug, 09, 2026

99 people who take Divigel and Zopiclone together, and have interactions are studied.

Divigel and Zopiclone drug interactions.

What are the common drug interactions of Divigel and Zopiclone, by gender? *:

female:

  1. Drug level increased
  2. Electrocardiogram qt prolonged
  3. Fatigue (feeling of tiredness)
  4. Haemoglobin decreased
  5. Abdominal pain
  6. Asthenia (weakness)
  7. Blood pressure increased
  8. Chest discomfort
  9. Chills (felling of cold)
  10. Decreased immune responsiveness

male:

n/a

What are the common drug interactions of Divigel and Zopiclone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Chills (felling of cold)
  2. Decreased immune responsiveness
  3. Defaecation urgency (a sudden compelling urge to defecate)
  4. Diarrhoea
  5. Feeling hot
  6. Gait disturbance
  7. Headache (pain in head)
  8. Hunger
  9. Influenza like illness
  10. Migraine (headache)

50-59:

  1. Pruritus (severe itching of the skin)

60+:

  1. Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
  2. Haemoglobin decreased

What are the existing conditions these people have? *

  1. Fever: 79 people, 79.80%
  2. Abdominal Discomfort: 78 people, 78.79%
  3. Mood Swings (an extreme or rapid change in mood): 76 people, 76.77%
  4. Rashes (redness): 75 people, 75.76%
  5. Pain: 75 people, 75.76%
  6. Joint Pain: 8 people, 8.08%
  7. Glaucoma (increased fluid pressure in the eye with vision loss): 8 people, 8.08%
  8. Sinusitis (inflammation of sinus): 7 people, 7.07%

* Approximation only. Some reports may have incomplete information.

Do you take Divigel and Zopiclone?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Divigel and Zopiclone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Divigel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Zopiclone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Divigel and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zopiclone and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on estradiol and eszopiclone (the active ingredients of Divigel and Zopiclone, respectively), and Divigel and Zopiclone (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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