Donepezil hydrochloride and Droxidopa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Donepezil hydrochloride (donepezil hydrochloride) and Droxidopa (droxidopa). Common drug interactions include dyspnoea among females and dysphagia among males.

The phase IV clinical study analyzes what interactions people have when they take Donepezil hydrochloride and Droxidopa. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Donepezil hydrochloride?

Donepezil hydrochloride has active ingredients of donepezil hydrochloride. It is often used in dementia. eHealthMe is studying from 4,263 Donepezil hydrochloride users. Check the latest studies of Donepezil hydrochloride.

What is Droxidopa?

Droxidopa has active ingredients of droxidopa. eHealthMe is studying from 1,093 Droxidopa users. Check the latest studies of Droxidopa.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 15, 2026

16 people who take Donepezil hydrochloride and Droxidopa together, and have interactions are studied.

Donepezil hydrochloride and Droxidopa drug interactions.

What are the common drug interactions of Donepezil Hydrochloride and Droxidopa, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Malaise (a feeling of general discomfort or uneasiness)
Gastric ulcer haemorrhage (bleeding ulcer of stomach)
Mobility decreased (ability to move is reduced)
Anaemia (lack of blood)
Constipation
Drooling (drop saliva uncontrollably from the mouth)
Dyslalia (inability to articulate comprehensible speech)
Hypoacusis (loss of hearing)
Nausea (feeling of having an urge to vomit)

male:

Dysphagia (a condition in which swallowing is difficult or painful)
Delusion (a false belief or opinion)
Diplegia (paralysis of corresponding parts on both sides of the body)
Dizziness
Fall
Hepatic steatosis (fatty liver disease)
Insomnia (sleeplessness)
Muscle rigidity (muscle stiffness)
Nausea (feeling of having an urge to vomit)
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)

What are the common drug interactions of Donepezil Hydrochloride and Droxidopa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Dyspnoea (difficult or laboured respiration)
Malaise (a feeling of general discomfort or uneasiness)
Hypoacusis (loss of hearing)
Asphyxia (a condition in which there is an extreme decrease in the concentration of oxygen in the body)
Dizziness
Fall
Gait disturbance
Hallucination (an experience involving the perception of something not present)
Hyperhidrosis (abnormally increased sweating)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)

What are the existing conditions these people have? *

Parkinson's Disease: 15 people, 93.75%
Osteoporosis (bones weak and more likely to break): 4 people, 25.00%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 4 people, 25.00%
Constipation: 4 people, 25.00%
Tremor (trembling or shaking movements in one or more parts of your body): 3 people, 18.75%
Orthostatic Hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 3 people, 18.75%
Neuroleptic Malignant Syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents): 3 people, 18.75%
Hepatic Steatosis (fatty liver disease): 3 people, 18.75%
Insomnia (sleeplessness): 2 people, 12.50%
Viraemia (presence of a virus in the blood stream): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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