Donepezil hydrochloride and Provigil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Donepezil hydrochloride (donepezil hydrochloride) and Provigil (modafinil). Common drug interactions include dizziness among females and hallucination among males.

The phase IV clinical study analyzes what interactions people have when they take Donepezil hydrochloride and Provigil. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Donepezil hydrochloride?

Donepezil hydrochloride has active ingredients of donepezil hydrochloride. It is often used in dementia. eHealthMe is studying from 4,263 Donepezil hydrochloride users. Check the latest studies of Donepezil hydrochloride.

What is Provigil?

Provigil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 25,230 Provigil users. Check the latest studies of Provigil.

On Jul, 18, 2026

19 people who take Donepezil hydrochloride and Provigil together, and have interactions are studied.

Donepezil hydrochloride and Provigil drug interactions.

What are the common drug interactions of Donepezil Hydrochloride and Provigil, by gender? *:

female:

Dizziness
Alopecia (absence of hair from areas of the body)
Hypoacusis (loss of hearing)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Agitation (state of anxiety or nervous excitement)
Application site reaction
Asthenia (weakness)
Balance disorder
Breast cancer

male:

Hallucination (an experience involving the perception of something not present)
Confusional state
Blood pressure increased
Dizziness
Dyskinesia (abnormality or impairment of voluntary movement)
Glaucoma (increased fluid pressure in the eye with vision loss)
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
International normalised ratio increased
Lung disorder (lung disease)
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)

What are the common drug interactions of Donepezil Hydrochloride and Provigil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dizziness
Nausea (feeling of having an urge to vomit)
Tremor (trembling or shaking movements in one or more parts of your body)
Urinary tract infection

50-59:

Asthenia (weakness)
Breast cancer
Influenza like illness
Malaise (a feeling of general discomfort or uneasiness)
Nasopharyngitis (inflammation of the nasopharynx)
Oropharyngeal pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pyrexia (fever)

60+:

Alopecia (absence of hair from areas of the body)
Balance disorder
Temperature intolerance (inability to go in temperature)
Cataract (clouding of the lens inside the eye)
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Cough
Decreased appetite
Depressed mood
Drug ineffective
Dysphagia (a condition in which swallowing is difficult or painful)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 31.58%
Varices Oesophageal (enlarged and swollen veins at the bottom of the oesophagus, near the stomach): 3 people, 15.79%
Parkinson's Disease: 3 people, 15.79%
Hypotension (abnormally low blood pressure): 3 people, 15.79%
High Blood Cholesterol: 3 people, 15.79%
Hallucinations (sensations that appear real but are created by your mind): 3 people, 15.79%
Glaucoma (increased fluid pressure in the eye with vision loss): 3 people, 15.79%
Delusion (a false belief or opinion): 3 people, 15.79%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 10.53%
Gait Disturbance: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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