Donepezil and Sumatriptan succinate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Donepezil (donepezil hydrochloride) and Sumatriptan succinate (sumatriptan succinate). Common drug interactions include depression among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Donepezil and Sumatriptan succinate. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Donepezil?

Donepezil has active ingredients of donepezil hydrochloride. It is often used in dementia. eHealthMe is studying from 24,564 Donepezil users. Check the latest studies of Donepezil.

What is Sumatriptan succinate?

Sumatriptan succinate has active ingredients of sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 9,731 Sumatriptan succinate users. Check the latest studies of Sumatriptan succinate.

On Jul, 25, 2026

46 people who take Donepezil and Sumatriptan succinate together, and have interactions are studied.

Donepezil and Sumatriptan succinate drug interactions.

What are the common drug interactions of Donepezil and Sumatriptan Succinate, by gender? *:

female:

Depression
Renal failure (kidney dysfunction)
Anxiety
Chronic kidney disease
Renal disorder (kidney disease)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Nausea (feeling of having an urge to vomit)
Malaise (a feeling of general discomfort or uneasiness)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Discomfort

male:

Renal failure (kidney dysfunction)
Nonspecific reaction (unspecified reaction)
Renal impairment (severely reduced kidney function)
Renal tubular necrosis (death of kidney tubules)
Haemorrhage (bleeding)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Emotional distress
Kidney infection

What are the common drug interactions of Donepezil and Sumatriptan Succinate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Glioblastoma (most common and most aggressive malignant primary brain tumour in humans)

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Anxiety
Depression
Renal disorder (kidney disease)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Renal impairment (severely reduced kidney function)
Renal tubular necrosis (death of kidney tubules)
Nephropathy (damage to or disease of a kidney)

50-59:

Anxiety
Chronic kidney disease
Renal failure (kidney dysfunction)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Dyspepsia (indigestion)
Emotional distress
Nausea (feeling of having an urge to vomit)
Osteonecrosis (death of bone)
Pain
Depression

60+:

Fatigue (feeling of tiredness)
Nonspecific reaction (unspecified reaction)
Asthenia (weakness)
Bedridden
Chronic kidney disease
Depression
Fall
General physical health deterioration (weak health status)
Hypertensive nephropathy (hypertensive renal disease)
Malaise (a feeling of general discomfort or uneasiness)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 26.09%
Parkinson's Disease: 11 people, 23.91%
Muscle Spasms (muscle contraction): 8 people, 17.39%
Pain: 6 people, 13.04%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 13.04%
Immunodeficiency Common Variable: 6 people, 13.04%
Stress And Anxiety: 4 people, 8.70%
Restless Leg Syndrome (a powerful urge to move your legs): 4 people, 8.70%
Blood Pressure Abnormal: 4 people, 8.70%
Fluid Retention (an abnormal accumulation of fluid in the blood): 3 people, 6.52%

* Approximation only. Some reports may have incomplete information.

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