Donepezil and Valacyclovir hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Donepezil (donepezil hydrochloride) and Valacyclovir hydrochloride (valacyclovir hydrochloride). Common drug interactions include constipation among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Donepezil and Valacyclovir hydrochloride. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Donepezil?

Donepezil has active ingredients of donepezil hydrochloride. It is often used in dementia. eHealthMe is studying from 24,564 Donepezil users. Check the latest studies of Donepezil.

What is Valacyclovir hydrochloride?

Valacyclovir hydrochloride has active ingredients of valacyclovir hydrochloride. It is often used in herpes zoster. eHealthMe is studying from 12,929 Valacyclovir hydrochloride users. Check the latest studies of Valacyclovir hydrochloride.

On Jul, 16, 2026

16 people who take Donepezil and Valacyclovir hydrochloride together, and have interactions are studied.

Donepezil and Valacyclovir hydrochloride drug interactions.

What are the common drug interactions of Donepezil and Valacyclovir Hydrochloride, by gender? *:

female:

Constipation
Diarrhoea haemorrhagic (bloody diarrhoea)
Anaemia (lack of blood)
Chronic kidney disease
Depression
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Heat illness
Liver injury
Renal failure (kidney dysfunction)

male:

Asthenia (weakness)
Heart rate decreased
Blood pressure increased
Blood sodium decreased
Blood urea increased
Cerebral small vessel ischaemic disease (inadequate blood supply to small blood vessel of brain)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Dementia alzheimer's type (loss of mental ability with alzheimer's symptom)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)

What are the common drug interactions of Donepezil and Valacyclovir Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Asthenia (weakness)
Heart rate decreased
Blood potassium increased
Blood pressure increased
Blood sodium decreased
Blood urea increased
Cerebral small vessel ischaemic disease (inadequate blood supply to small blood vessel of brain)
Chronic kidney disease
Constipation
Depression

What are the existing conditions these people have? *

Pain: 4 people, 25.00%
Mantle Cell Lymphoma (cancer of lymphocytes, a type of white blood cell): 3 people, 18.75%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 12.50%
Multiple Myeloma (cancer of the plasma cells): 2 people, 12.50%
Stress And Anxiety: 2 people, 12.50%
High Blood Pressure: 2 people, 12.50%
Type 2 Diabetes: 1 person, 6.25%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 6.25%
Back Pain: 1 person, 6.25%
Bone Pain: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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