Donepezil and Vimpat drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Donepezil (donepezil hydrochloride) and Vimpat (lacosamide). Common drug interactions include head injury among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Donepezil and Vimpat. It is created by eHealthMe based on reports of 87 people who take the same drugs from the FDA, and is updated regularly.

What is Donepezil?

Donepezil has active ingredients of donepezil hydrochloride. It is often used in dementia. eHealthMe is studying from 24,564 Donepezil users. Check the latest studies of Donepezil.

What is Vimpat?

Vimpat has active ingredients of lacosamide. It is often used in epilepsy. eHealthMe is studying from 20,831 Vimpat users. Check the latest studies of Vimpat.

On Jul, 31, 2026

87 people who take Donepezil and Vimpat together, and have interactions are studied.

What are the common drug interactions of Donepezil and Vimpat, by gender? *:

female:

Head injury
Urinary tract infection
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Tremor (trembling or shaking movements in one or more parts of your body)
Anger
Bruxism (habitual grinding of the teeth, typically during sleep)
Drug eruption (adverse drug reaction of the skin)
Pneumonia
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Vomiting

male:

Fall
Asthenia (weakness)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Muscular weakness (muscle weakness)
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Lymphocyte count decreased
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
Platelet count decreased
Activated partial thromboplastin time prolonged
Alanine aminotransferase increased

What are the common drug interactions of Donepezil and Vimpat, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Aggression
Ammonia increased
Balance disorder
Encephalopathy (functioning of the brain is affected by some agent or condition)
Migraine (headache)
Nausea (feeling of having an urge to vomit)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Speech disorder
Suicidal ideation
Vomiting

30-39:

Loss of consciousness
Syncope (loss of consciousness with an inability to maintain postural tone)

40-49:

Alanine aminotransferase increased
Anion gap decreased
Balance disorder
Blood albumin decreased
Blood alkaline phosphatase decreased
Blood calcium decreased
Blood creatine decreased
Blood thyroid stimulating hormone increased
Body temperature decreased
Carbon dioxide increased

50-59:

Multiple-drug resistance

60+:

Fall
Dizziness
Loss of consciousness
Tremor (trembling or shaking movements in one or more parts of your body)
Abnormal behaviour
Blood glucose increased
Cerebellar ataxia (loss of coordination)
Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
Cerebral disorder (brain disease)
Dementia alzheimer's type (loss of mental ability with alzheimer's symptom)

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 27 people, 31.03%
Constipation: 15 people, 17.24%
Stress And Anxiety: 13 people, 14.94%
Parkinson's Disease: 13 people, 14.94%
Pain: 13 people, 14.94%
Depression: 12 people, 13.79%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 10 people, 11.49%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 9 people, 10.34%
Sleep Disorder: 8 people, 9.20%
Nausea (feeling of having an urge to vomit): 8 people, 9.20%

* Approximation only. Some reports may have incomplete information.

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